ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1617787
This article is part of the Research TopicAdvancing Biomarker Discovery, Molecular Mechanisms, and Immunological Insights in Tumor Precision MedicineView all articles
Prognostic value of positive lymph node ratio, tumor deposit, and perineural invasion in advanced colorectal signet-ring cell carcinoma
Provisionally accepted
Liang Chu1
Han Wang2
LING TAO3Shuhan Feng4Yucheng Ding1Yan Zhang1Ying Pan5
Cenzhu Wang6Xiaohong Wang7
Lei Liu1*- 1The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, China, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, China, China
- 2hainan medical university, hainan, China
- 3Jinhua Central Hospital, Jinhua, 321000, China, Jinhua, China
- 4The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, China, jiangsu, China
- 5Nanjing Drum Tower Hospital Affiliated to Nanjing University Medical School,, Nanjing 210011, China
- 6Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu Province, China
- 7Xuzhou Central Hospital, Xuzhou, Jiangsu Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The aim of this study was to assess the prognostic significance of positive lymph node ratio (LNR), tumor deposits (TD), and perineural invasion (PNI) in advanced colorectal signet-ring cell carcinoma (SRCC).: A multicenter retrospective cohort analysis was conducted involving 677 patients with advanced colorectal SRCC. The associations of variables with CSS and OS were analyzed using the Kaplan-Meier method and multivariable Cox proportional hazards models. A nomogram model was developed to predict outcomes. Results: High-LNR, TD-positive, and PNI-positive were associated with poorer CSS and OS in both the training and validation cohorts. Multivariate Cox analysis identified T stage, M stage, TD, CEA, chemotherapy, and LNR as independent prognostic factors. A prognostic nomogram model incorporating these variables demonstrated excellent calibration and satisfactory predictive accuracy. Survival curves generated from individualized nomogram scores effectively discriminated prognostic outcomes (P<0.001). The combined variable of LNR, TD, and PNI significantly enhanced the predictive performance. Specifically, the combined variable exhibited the highest relative contribution to OS at 23.4%, surpassing that of T and M stages. For CSS, its relative contribution was 21.4%, ranking second only to T and M stages. Conclusion: LNR, TD, and PNI served as prognostic factors for advanced colorectal SRCC. The combined analysis demonstrated a higher prognostic predictive value.
Keywords: colorectal signet ring cell carcinoma, lymph node ratio, tumor deposit, Perineural invasion, prognosis
Received: 25 Apr 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Chu, Wang, TAO, Feng, Ding, Zhang, Pan, Wang, Wang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Liu, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, China, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, 214200, China, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.