ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Metabolomics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1618014
An exploratory study of urinary proteome in trigeminal neuralgia
Provisionally accepted
- 1China-Japan Friendship Hospital, Beijing, China
- 2Gene Engineering Drug and Biotechnology Beijing Key Laboratory, College of Life Sciences，Beijing Normal University, Beijng, China
- 3Institute of Clinical Medicine, National Infrastructure for Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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Background Trigeminal neuralgia (TN) is a neurological disorder characterized by severe pain and a complex pathogenesis. This condition seriously affects patients' quality of life. The analysis of urinary proteomics has shown great potential in disease research. Objective The aim of this study is to explore the diagnostic and therapeutic value of urine proteomics in TN. Method The urine of 10 cases of TN and 11 healthy individuals were studied using liquid chromatography-mass spectrometry (LC-MS) proteomics technology. Group analysis and one to many individual analysis strategies were used in quantitative analysis. Result A total of 2 620 proteins were identified in the group analysis, and 1 883 of them were quantifiable. Most specimens in each group were distinguishable through clustering analysis of the urinary proteome. Significant enrichment was observed in biological processes such as immune response-regulating signaling pathway, regulation of complement activation, natural killer cell inhibitory signaling pathway, and cytoplasmic translation, as well as in KEGG pathways including antigen processing and presentation, and complement and coagulation cascades. Individual analysis revealed a higher number of significantly different proteins between patients, with seven proteins identified in at least nine patients. Conclusion The urinary proteome provided molecular characteristics of urinary proteins in patients. It described the changes that occur in the patient's body. The strong enrichment of immune response pathways may be linked to disease onset, suggesting new avenues for immune-based treatments, and the significant differential proteins could become potential disease markers for diagnosis and treatment evaluation.
Keywords: Neuropathy, Disease markers, Urinary proteomics, Trigeminal Neuralgia, immunereaction
Received: 28 Apr 2025; Accepted: 15 Oct 2025.
Copyright: © 2025 Wei, Wang, Zhou, Wu, Cao, Zhan and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongtong Cao, caoyongtong100@sina.com
Yuliang Zhan, zylzryhyy@163.com
Youhe Gao, gaoyouhe@bnu.edu.cn
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