REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1625962
This article is part of the Research TopicAdvancing Biomarker Discovery, Molecular Mechanisms, and Immunological Insights in Tumor Precision MedicineView all 3 articles
Structure, function, and pathology of PHF23
Provisionally accepted
- Chongqing Medical University, Chongqing, China
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PHF23 (Plant Homeodomain Finger Protein 23) is a member of the Plant Homeodomain (PHD) finger protein family and has been extensively reported since its discovery. Numerous studies have demonstrated that PHF23 plays a crucial role in various biological processes, such as gene expression regulation, autophagy, and tumorigenesis. Additionally, PHF23 is associated with various diseases including various malignancies, osteoarthritis, and tuberculosis, all of which currently lack effective and targeted treatment options. Therefore, this review systematically summarizes the existing literature on PHF23, and provides a comprehensive overview of the structure and function of PHF23, and focuses on its relationship with multiple diseases.We aim to advance PHF23 research to establish it as a novel therapeutic and diagnostic target, offering new hope for patients with related diseases while reducing adverse clinical outcomes.
Keywords: PHF23, PHD domain, Epigenetic regulation, tumor, degenerative disease
Received: 09 May 2025; Accepted: 30 Jun 2025.
Copyright: © 2025 Liu, Liu, Liu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gangming Wu, Chongqing Medical University, Chongqing, China
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