REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1653627
The Emerging Role of Exosomal LncRNAs in Chronic Fatigue Syndrome: From Intercellular Communication to Disease Biomarkers
Provisionally accepted
Lei Wang1Yujia Xu2Xiang Zhong3Guiping Wang2Zijun Shi2Can Mei2Linwanyue Chen2Jianbo Zhan4*
Jing Cheng2,5*- 1China University of Geosciences, Wuhan, China
- 2Wuhan University of Science and Technology School of Medicine, Wuhan, China
- 3Yangtze University Medical School, Jingzhou, China
- 4Hubei Provincial Center for Disease Control and Prevention, Wuhan, China
- 5Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, China
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Chronic fatigue syndrome (CFS) is a complex disease involving multiple systems throughout the body with unknown pathogenesis and is characterized by chronic fatigue. To date, no effective treatment for CFS has been found, as well as biomarkers for early identification of diagnosis. However, exosomes, a subpopulation of extracellular vesicles (EVs), are membranous vesicles secreted by cells into the surrounding environment, and long noncoding RNAs (LncRNAs) in EVs can mediate inter-organ and inter-cellular communication, which maybe associate with CFS. Therefore, this study aims to review the association between EV-LncRNAs and CFS, and to explore whether LncRNAs can be used as potential biomarkers for early identification and diagnosis of CFS, which put forward new ideas and a theoretical basis for the pathogenesis of CFS, as well as the identification of novel targeted therapies.
Keywords: Exosomes, lncRNAs, chronic fatigue syndrome, Association, biomarkers
Received: 27 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Wang, Xu, Zhong, Wang, Shi, Mei, Chen, Zhan and Cheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jianbo Zhan, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China
Jing Cheng, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, China
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