REVIEW article
Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1661697
This article is part of the Research TopicEmerging Paradigms in Understanding Cancer Metastasis: Focus on Tumor Microenvironment DynamicsView all 5 articles
Insights into recent findings and therapeutic potential of nonhistone lactylation in cancer Authors' names and affiliations
Provisionally accepted
- 1First People's Hospital of Kunshan, Kunshan, China
- 2Katholieke Universiteit Leuven, Leuven, Belgium
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Lactylation, a recently identified post-translational modification, has become a crucial regulatory mechanism beyond its conventional metabolic role. Unlike histone lactylation, which regulates gene expression, nonhistone lactylation directly acts on effector proteins involved in processes such as signal transduction, metabolic reprogramming, and DNA damage repair. This article systematically reviews how nonhistone lactylation regulates biological processes related to cancer via mechanisms such as modulating protein interactions, stability, subcellular localization, and enzymatic activity. In addition, it comprehensively examines the potential applications and challenges in targeting nonhistone lactylation modification in antitumor treatment.
Keywords: Nonhistone, lactylation, post-translational modification, Anti-tumor therapy, Cancer Metabolism
Received: 08 Jul 2025; Accepted: 19 Aug 2025.
Copyright: © 2025 Jia, Liu, Zhu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jing Jia, First People's Hospital of Kunshan, Kunshan, China
Min-bin Chen, First People's Hospital of Kunshan, Kunshan, China
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