REVIEW article
Front. Mol. Biosci.
Sec. Cellular Biochemistry
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1666874
Post-Translational Modifications in Heat Stress-Related Diseases
Provisionally accepted
- 1Clinical Laboratory, Department of Oncology, Bethune International Peace Hospital, Shijiazhuang, China
- 2The 980th Hospital of the People's Liberation Army Joint Logistics Support Force, Shijiazhuang, China
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Post-translational modifications (PTMs) act as pivotal molecular hubs integrating heat stress signals into cellular responses driving heat-related diseases like heatstroke. This review synthesizes evidence demonstrating that dynamic PTM networks—including phosphorylation, acetylation, ubiquitination, methylation, SUMOylation, and S-nitrosylation—orchestrate pathophysiology through three distinctive mechanisms: PTM crosstalk, tissue-specific PTM signatures defining organ vulnerability, and translational utility. The potentials of PTM alterations as novel biomarkers for early diagnosis/prognosis and PTM-targeted interventions as therapeutic strategies are discussed. By delineating how PTMs reconfigure proteostasis, metabolism, and inflammation, this review provides a mechanistic framework for targeting PTM pathways to mitigate heatstroke and related conditions.
Keywords: Heat stress, post-translational modifications, Phosphorylation, Acetylation, Ubiquitination, Methylation, S-nitrosylation
Received: 17 Jul 2025; Accepted: 26 Aug 2025.
Copyright: © 2025 Wang, Cui, Jia, Li and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fukun Wang, Clinical Laboratory, Department of Oncology, Bethune International Peace Hospital, Shijiazhuang, China
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