REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers
Provisionally accepted
- 1Laboratory of inflammation immunomorphology, Avtsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution «Petrovsky National Research Centre of Surgery»,, Moscow, Russia
- 2Petrovsky Medical University, Moscow, Russia
- 3Faculty of Biology and Biotechnology, HSE University, Moscow, Russia
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Humans and laboratory animals differ in their resistance to hypoxia, which affects the severity of 15 inflammatory diseases and the rate of tumor progression. Therefore, it is necessary to search for 16 methods for assessing the initial tolerance to oxygen deficiency and the risks of developing acute 17 mountain sickness without direct hypoxia exposure on the organism. The literature describes 18 assessments of oxygen deficiency tolerance assessing based on physiological and molecular 19 parameters. The limitations of such methods include the need of expensive equipment use and highly 20 qualified specialists involvement. In addition, in the studies presented in this review, the altitude, 21 time and methods for achieving it, as well as the frequency of assessing the severity of acute 22 mountain sickness varied significantly. It is necessary to continue research aimed at investigating 23 biomarkers of tolerance to oxygen deficiency without direct hypoxia exposure using instrumental 24 and laboratory diagnostics. This will allow developing new approaches for personalized prevention, 25 diagnosis and treatment of inflammatory diseases and malignancies and, accordingly, improve the 26 quality of life.
Keywords: hypoxia, biomarkers, hypoxia tolerance, acute mountain sickness, personalized medicine
Received: 28 Jul 2025; Accepted: 12 Nov 2025.
Copyright: © 2025 Silina, Dzhalilova, Fokichev and Makarova. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maria Silina, marusyasilina99@yandex.ru
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.