REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1680908
This article is part of the Research TopicIdentifying Molecular Biomarkers Using Multi-Omics or Liquid Biopsy for Early Detection and Disease Monitoring of CancerView all articles
Dual-Regulatory miRNAs: Master Regulators and Therapeutic Targets in Bone-Metastatic Breast Cancer
Provisionally accepted
- 1Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China
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Breast cancer bone metastasis involves dynamic reprogramming of transcriptional networks and cellular homeostasis. Current primary treatment strategy relies on palliative care, and the search for effective therapeutic targets remains a critical challenge. MicroRNAs (miRNAs), endogenous non-coding RNA molecules, exert precise regulation of gene expression through sequence-specific binding to the 3' UTR of target mRNAs. Accumulating evidence has established miRNAs as pivotal regulators of breast cancer and its metastatic bone disease. Depending on their target genes, individual miRNAs may function as oncogenic miRNAs (oncomiRs) or as tumor suppressor miRNAs (tsmiRs), and hold potential as biomarkers for diagnosis and prognosis. This review systematically analyzes the regulatory mechanisms of critical miRNAs and their target genes in breast cancer bone metastasis, offering novel insights for early diagnosis and targeted therapeutic strategies.
Keywords: miRNAs, breast cancer, bone metastasis, targeted therapy, bone microen-vironment
Received: 06 Aug 2025; Accepted: 13 Oct 2025.
Copyright: © 2025 Meng, Zhang, Pu, Shi and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jingwei Li, mengfeifei@sdzyydxdylcyx.wecom.work
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