REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1694131
This article is part of the Research TopicThe Role of Calcium Channels in Human Health and Disease Volume IIIView all 13 articles
Mechanistic Insights into Cisplatin-Induced Ototoxicity: The Central Role of Transient Receptor Potential Channels
Provisionally accepted
- 1Zunyi Medical University - Zhuhai Campus, Zhu hai, China
- 2Longgang Otolaryngology Hospital, Shenzhen, China
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This review systematically elucidates the molecular mechanisms underlying cisplatin-induced ototoxicity, with a particular focus on the pivotal role played by TRP channels. First, the article outlines the uptake and efflux pathways of cisplatin within cochlear hair cells, followed by a detailed analysis of the core mechanisms by which cisplatin damages these cells. It emphasizes the structural and functional characteristics of TRP channels and their action mechanisms in cisplatin ototoxicity, elucidating the channels' high selectivity for calcium ions and their central role in driving ototoxicity. Additionally, the review explores the roles of other TRP family members in regulating hair cells. Finally, based on an analysis of the limitations of existing otoprotective strategies, the review proposes future precision prevention and treatment strategies targeting TRP channels. These include novel nanodelivery technologies and multi-pathway combined interventions, providing a new theoretical foundation and translational direction for protecting against cisplatin ototoxicity.
Keywords: Transient Receptor Potential Channels, Cisplatin, cochlear hair cells, Calcium, therapy
Received: 28 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Yu, Li and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xianhai Zeng, zxhklwx@163.com
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