REVIEW article
Front. Mol. Neurosci.
Sec. Brain Disease Mechanisms
Volume 18 - 2025 | doi: 10.3389/fnmol.2025.1617771
This article is part of the Research TopicProteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategiesView all 4 articles
Role of the Chaperonin TCP-1 Ring Complex (TRiC) in Protein Aggregation and Neurodegeneration
Provisionally accepted
- Neurology, University of Florida, Gainesville, Florida, United States
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The chaperonin TCP-1 ring complex (TRiC), also known as chaperonin-containing TCP-1 (CCT) complex, plays a crucial role in protein folding and quality control within the cell. Comprising eight distinct subunits (CCT1 -CCT8), TRiC assists in the folding of a wide range of client proteins, ensuring their proper conformation and functionality. This mini review explores the assembly, structure, and cellular functions of TRiC and discusses its involvement in protein aggregation and neurodegenerative diseases. We emphasize the emerging role of CCT2 in modulating the formation of abnormal amyloid aggregates, including amyloid beta, tau, and polyglutamine (polyQ) deposits, which are central to the pathogenesis of various neurological conditions. Lastly, we provide evidence supporting the neuroprotective role of CCT2 in vivo and also highlight therapeutic implications and key unresolved questions in the field, offering a foundation for new research opportunities.
Keywords: Aggrephagy, Alzheimer, Amyloid beta, CCT complex, chaperonin, PolyQ, tau, TRIC
Received: 24 Apr 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Varte and Rincon-Limas. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Diego E Rincon-Limas, Neurology, University of Florida, Gainesville, 32611, Florida, United States
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