Proteostasis disruption in neurodegenerative disorders: Mechanisms and treatment strategies

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REVIEW

Published on 01 May 2025

NFE2L1 as a central regulator of proteostasis in neurodegenerative diseases: interplay with autophagy, ferroptosis, and the proteasome

Hossein Khodadadi
Kamila Łuczyńska
Dawid Winiarczyk
Paweł Leszczyński
Hiroaki Taniguchi

doi 10.3389/fnmol.2025.1551571

714 views

ORIGINAL RESEARCH

Published on 20 Feb 2025

Multi-omics-based phenotyping of AFG3L2-mutant lymphoblasts determines key factors of a pathophysiological interplay between mitochondrial vulnerability and neurodegeneration in spastic ataxia type 5

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Kale Dipali
Andreas Hentschel
Nina Rademacher
Florian Kraft
Rita Horvath
Felix Distelmaier
Sven G. Meuth
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Andreas Roos

doi 10.3389/fnmol.2025.1548255

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REVIEW

Published on 23 Oct 2024

Liquid–liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson’s disease pathogenesis

Eva D. Ruiz-Ortega
Anna Wilkaniec
Agata Adamczyk

doi 10.3389/fnmol.2024.1494218

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Frontiers in Molecular Neuroscience

Frontiers in Molecular Neuroscience

Brain Disease Mechanisms

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