Frontiers in Molecular Neuroscience | Pain Mechanisms and Modulators

Review

Published on 09 Sep 2024

The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization

in Pain Mechanisms and Modulators

Ning Gao
Meng Li
Weiming Wang
Zhen Liu
Yufeng Guo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1400118

18,479 views
42 citations

Original Research

Published on 03 Sep 2024

Reward system neurodynamics during menstrual pain modulated by COMT Val158Met polymorphisms

in Pain Mechanisms and Modulators

Pei-Shan Hsu
Ching-Hsiung Liu
Ching-Ju Yang
Lin-Chien Lee
Wei-Chi Li
Hsiang-Tai Chao
Ming-Wei Lin
Li-Fen Chen
Jen-Chuen Hsieh

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1457602

3,797 views
1 citation

Original Research

Published on 30 Aug 2024

Dock4 contributes to neuropathic pain by regulating spinal synaptic plasticity in mice

in Pain Mechanisms and Modulators

Qiaochu Fu
Hongyi Li
Zhuanxu Zhu
Wencui Li
Zhihua Ruan
Ruijie Chang
Huixia Wei
Xueqin Xu
Xunliang Xu
Yanqiong Wu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1417567

2,870 views

Original Research

Published on 06 Aug 2024

Coordination between midcingulate cortex and retrosplenial cortex in pain regulation

in Pain Mechanisms and Modulators

Yunya Qiu
Yan-Na Lian
Cheng Wu
Li Liu
Chen Zhang
Xiang-Yao Li

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1405532

2,395 views
3 citations

Original Research

Published on 17 Jul 2024

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

in Pain Mechanisms and Modulators

Gerald Z. Zhuang
William F. Goins
Munal B. Kandel
Marco Marzulli
Mingdi Zhang
Joseph C. Glorioso
Yuan Kang
Alexandra E. Levitt
Konstantinos D. Sarantopoulos
Roy C. Levitt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1416148

4,305 views
3 citations

Mini Review

Published on 26 Jun 2024

Treadmill running on neuropathic pain: via modulation of neuroinflammation

in Pain Mechanisms and Modulators

Wei-Chun He
Shuang-Long Hou
Kai-Bin Wang
Ning Xu
Ke Li
Ting Xiong
Jing Luo

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1345864

4,274 views
2 citations

Original Research

Published on 24 Jun 2024

Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors

in Pain Mechanisms and Modulators

Casey I. Gallagher
David P. Bishop
Thomas E. Lockwood
Tristan Rawling
Robert J. Vandenberg

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1392715

2,119 views
1 citation

Original Research

Published on 22 May 2024

SIRT1-regulated ROS generation activates NMDAR2B phosphorylation to promote central sensitization and allodynia in a male chronic migraine rat model

in Pain Mechanisms and Modulators

Xiaoyan Zhang
Wei Zhang
Yanyun Wang
Yun Zhang
Dunke Zhang
Guangcheng Qin
Jiying Zhou
Lixue Chen

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1387481

3,777 views
6 citations

Original Research

Published on 09 May 2024

GnRH peripherally modulates nociceptor functions, exacerbating mechanical pain

in Pain Mechanisms and Modulators

Haiyan Zheng
Minseok Kim
Chaeun Kim
Yerin Kim
Pyung Sun Cho
Ji Yeon Lim
Hojin Lee
Hye-In Yun
Jungmin Choi
Sun Wook Hwang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1160435

2,916 views

Original Research

Published on 09 May 2024

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

in Pain Mechanisms and Modulators

Munal B. Kandel
Gerald Z. Zhuang
William F. Goins
Marco Marzulli
Mingdi Zhang
Joseph C. Glorioso
Yuan Kang
Alexandra E. Levitt
Wai-Meng Kwok
Roy C. Levitt

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1398839

4,469 views
6 citations

Original Research

Published on 01 May 2024

Behavioral and pharmacological characterization of planarian nociception

in Pain Mechanisms and Modulators

Guillaume Reho
Yannick Menger
Yannick Goumon
Vincent Lelièvre
Hervé Cadiou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1368009

5,568 views
6 citations

Review

Published on 26 Mar 2024

Acupuncture for radicular pain: a review of analgesic mechanism

in Pain Mechanisms and Modulators

Hong-Lin Li
Yi Zhang
Jian-Wei Zhou

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1332876

11,950 views
14 citations

Review

Published on 28 Feb 2024

Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics

in Pain Mechanisms and Modulators

Kofi Frimpong-Manson
Yuma T. Ortiz
Lance R. McMahon
Jenny L. Wilkerson

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1355281

36,127 views
33 citations

Original Research

Published on 21 Feb 2024

Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features

in Pain Mechanisms and Modulators

Myeong Seong Bak
Haney Park
Heera Yoon
Geehoon Chung
Hyunjin Shin
Soonho Shin
Tai Wan Kim
Kyungjoon Lee
U. Valentin Nägerl
Sang Jeong Kim

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1356453

5,604 views

Original Research

Published on 14 Feb 2024

Tetrandrine alleviates oxaliplatin-induced mechanical allodynia via modulation of inflammation-related genes

in Pain Mechanisms and Modulators

Zhi-Ling Zhang
Zi-Yang Wu
Feng-Yu Liu
Hang-YuChen
Suo-Di Zhai

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1333842

6,451 views
7 citations

Original Research

Published on 06 Feb 2024

Exploring gene signatures and regulatory networks in a rat model of sciatica: implications and validation in neuropathic pain

in Pain Mechanisms and Modulators

Mu Xu
Zhijian Wang
Gang Xu
Mengye Zhu
Daying Zhang
Yi Yan

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1261217

2,867 views

Mini Review

Published on 30 Jan 2024

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

in Pain Mechanisms and Modulators

Shan Wang
Shu-Hao Du
Xue-Qiang Wang
Jun-Yan Lu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2024.1269636

8,614 views
6 citations

Review

Published on 22 Dec 2023

Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications

in Pain Mechanisms and Modulators

Yongzi Wu
Chenxia Han
Rong Luo
Wenhao Cai
Qing Xia
Ruotian Jiang
Pawel E. Ferdek
Tingting Liu
Wei Huang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1331438

8,899 views
9 citations

Original Research

Published on 07 Dec 2023

Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury

in Pain Mechanisms and Modulators

Bruno Pradier
Daniel Segelcke
Sylvia Reichl
P. K. Zahn
E. M. Pogatzki-Zahn

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1282151

2,632 views
6 citations

Original Research

Published on 26 Oct 2023

Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch

in Pain Mechanisms and Modulators

Dong-Jin Li
Zhen-Juan Zhong
Xiao-Liang Wang
Na Wei
Si-Jia Zhao
Ting-Ting Shan
Ya-Ping Liu
Yao-Qing Yu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1279237

3,126 views
2 citations

Original Research

Published on 04 Oct 2023

Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons

in Pain Mechanisms and Modulators

Lamei Li
Yuanying Liu
Wenchao Hu
Jing Yang
Suibin Ma
Zhicheng Tian
Zixuan Cao
Kunqing Pan
Ming Jiang
Xia Liu

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1144614

5,461 views
14 citations

Editorial

Published on 28 Sep 2023

Editorial: Inflammatory pain: mechanisms, assessment, and intervention

in Pain Mechanisms and Modulators

Yong-Hui Zhang
Daniela Adamo
Howe Liu
Quanxing Wang
Wen Wu
Yi-Li Zheng
Xue-Qiang Wang

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1286215

13,743 views
19 citations

Mini Review

Published on 12 Sep 2023

A tactile twist: decoding the phenomena of mechanical itch and alloknesis

in Pain Mechanisms and Modulators

Taylor Follansbee
Xinzhong Dong

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1278151

7,435 views
4 citations

Review

Published on 17 Aug 2023

Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications

in Pain Mechanisms and Modulators

Huan-Jun Lu
Xiao-Bo Wu
Qian-Qi Wei

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2023.1239599

5,008 views
11 citations

339 articles

articles

The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization

Reward system neurodynamics during menstrual pain modulated by COMT Val158Met polymorphisms

Dock4 contributes to neuropathic pain by regulating spinal synaptic plasticity in mice

Coordination between midcingulate cortex and retrosplenial cortex in pain regulation

Disease-modifying rdHSV-CA8* non-opioid analgesic gene therapy treats chronic osteoarthritis pain by activating Kv7 voltage-gated potassium channels

Treadmill running on neuropathic pain: via modulation of neuroinflammation

Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors

SIRT1-regulated ROS generation activates NMDAR2B phosphorylation to promote central sensitization and allodynia in a male chronic migraine rat model

GnRH peripherally modulates nociceptor functions, exacerbating mechanical pain

rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels

Behavioral and pharmacological characterization of planarian nociception

Acupuncture for radicular pain: a review of analgesic mechanism

Advances in understanding migraine pathophysiology: a bench to bedside review of research insights and therapeutics

Machine learning-based evaluation of spontaneous pain and analgesics from cellular calcium signals in the mouse primary somatosensory cortex using explainable features

Tetrandrine alleviates oxaliplatin-induced mechanical allodynia via modulation of inflammation-related genes

Exploring gene signatures and regulatory networks in a rat model of sciatica: implications and validation in neuropathic pain

Mechanisms of transcranial direct current stimulation (tDCS) for pain in patients with fibromyalgia syndrome

Molecular mechanisms of pain in acute pancreatitis: recent basic research advances and therapeutic implications

Spinal GABA transporter 1 contributes to evoked-pain related behavior but not resting pain after incision injury

Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch

Peripheral CCL2 induces inflammatory pain via regulation of Ih currents in small diameter DRG neurons

Editorial: Inflammatory pain: mechanisms, assessment, and intervention

A tactile twist: decoding the phenomena of mechanical itch and alloknesis

Ion channels in cancer-induced bone pain: from molecular mechanisms to clinical applications