REVIEW article
Front. Nanotechnol.
Sec. Biomedical Nanotechnology
Volume 7 - 2025 | doi: 10.3389/fnano.2025.1611126
Antimicrobial Nanoparticles: A New Horizon to Combat Multidrug-Resistant Bacteria
Provisionally accepted- Dayalbagh Educational Institute, Agra, India
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Antimicrobial nanoparticles (NPs) exhibit revolutionary potential against infections due to their unique physicochemical properties that enhance antimicrobial activity. Antimicrobial NPs employ various mechanisms and pathways, including ROS generation, cell membrane disruption, DNA and protein damage, interfering metabolic pathways, and the electron transport chain, that eventually lead to microbial cell death. They are more beneficial than conventional antibiotics and have broad-spectrum efficacy with lower risk of resistance. Specifically, antibacterial NPs have a wide range of applications in various fields, such as food safety such as food safety (e.g., antimicrobial packaging), water purification, healthcare (e.g., wound healing, coatings on medical devices), agriculture (e.g., disease management, plant protection), and industrial products (e.g., textiles, personal care items). Despite their promising potential, challenges such as toxicity, environmental impact, and regulatory limitations remain critical for their sustainable use. This review aims to provide the critical insights of the various antibacterial NPs applications, mechanisms of action, and future scope, with highlighting their potential prospects for safe and optimal use.
Keywords: Nanoparticle (NPs), Multiple drug resistance (MDR), Minimum InhibitoryConcentration (MIC), Nanotherapeutics, reactive oxygen species (ROS)
Received: 13 Apr 2025; Accepted: 20 Oct 2025.
Copyright: © 2025 Chaturvedi and Ranjan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Rajiv Ranjan, rajivranjanbt@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.