SYSTEMATIC REVIEW article
Front. Ophthalmol.
Sec. Neuro-Ophthalmology Disorders
Effectiveness of Steroid Injection and Intravenous Immunoglobulin Therapy in Peripheral Neuropathy: A Literature Review
Imada Khoironi 1
Rahmanita Afina Arsaputri 2
Muhammad falah ghani Nuruddin 3
R. Mohamad Javier 4
Muhamad Zulfikar Hadiaturahman 5
magistra manalu 6
1. Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia, Central Java
2. Fakultas Kedokteran, Universitas Jenderal Achmad Yani, Cimahi, Indonesia, West Java
3. Islamic University of Indonesia, Yogyakarta, Indonesia, Special Region of Yogyakarta, 55584
4. RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia, Jakarta, 10430
5. Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia, Jakarta, 13630
6. Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia, Jakarta, 12930
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Abstract
Optic neuritis, or inflammation of the optic nerve, is a common cause of acute optic nerve injury in both children and adults. There are various causes of optic nerve inflammation, including autoimmunity, infection, granulomatous disease, paraneoplastic syndromes, and demyelination. Optic neuritis (both demyelinating and non-demyelinating) with inflammation as the underlying cause of injury is treated with steroids due to their anti-inflammatory properties. The administration of intravenous immunoglobulin, such as sulfonated immunoglobulin G (IgG), provides anti-inflammatory and neuroprotective effects in cases of optic neuritis.This study employs a literature review methodology, utilizing a list of relevant keywords and subheadings to conduct a comprehensive search of articles evaluated in two computerized databases: PubMed and Google Scholar. The research articles included clinical trials or randomized controlled trials. All identified research articles were evaluated based on their titles and abstracts, and selected according to inclusion and exclusion criteria. This review examines six studies that demonstrate the effectiveness of steroid injections compared to intravenous immunoglobulin injections in patients with neuritis.The prognosis and treatment of optic neuritis vary, depending on the underlying cause, duration, and severity of the condition. Optimal care requires prompt diagnosis, effective treatment, and the use of intravenous corticosteroids.
Summary
Keywords
Optic Neuritis, Intravenous corticosteroids, immunoglobulin, Acute demyelinating optic neuritis, Multiple Sclerosis
Received
11 December 2024
Accepted
26 February 2025
Copyright
© 2025 Khoironi, Arsaputri, ghani Nuruddin, Javier, Zulfikar Hadiaturahman and manalu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Imada Khoironi
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.