CASE REPORT article
Front. Ophthalmol.
Sec. Oculoplastics, Orbit and Trauma
Case Report: Bilateral Perineuroma of the Orbit Presenting as Vertical Binocular Diplopia
Provisionally accepted
- School of Medicine, University of Kansas Medical Center, Kansas City, United States
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In this case report we discuss a 65-year-old female who presented to ophthalmology clinic with vertical binocular diplopia of around 2 years duration. Visual exam was notable for bilateral proptosis and ophthalmoplegia. A Computed Tomography (CT) head scan revealed bilateral enhancing orbital masses. A biopsy was obtained which stained positive for Epithelial Membrane Antigen (EMA) and CD34 confirming a diagnosis of perineuroma. This is the first study to report the presence of bilateral perineuroma of the orbit, a rare location for an already uncommon benign tumor.
Keywords: diplopia5, orbit2, orbital tumor4, perineuroma1, peripheral nerve sheath tumor3
Received: 29 Dec 2025; Accepted: 06 Feb 2026.
Copyright: © 2026 Hertel, Boyle and Sokol. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amanda K Hertel
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