Frontiers in Physiology | Gastrointestinal Sciences

Review

Published on 13 May 2026

Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies

in Gastrointestinal Sciences

Dominika Stygar
Bartosz Bogielski
Katarzyna Michalczyk
Bronisława Skrzep-Poloczek
Alicja Suchocka
Kamil Nikiel
Kazimierz Kukla
Rafał Wasek
Jakub Staniszewski
Maciej Matyja

Frontiers in Physiology

doi 10.3389/fphys.2026.1788973

285 views

Original Research

Published on 08 May 2026

Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro

in Gastrointestinal Sciences

Dulantha Ulluwishewa
Ajitpal Purba
Vincent Fegan
Narsaa Na
Simon J. O’Carroll
Rachel C. Anderson

Frontiers in Physiology

doi 10.3389/fphys.2026.1808663

386 views

Original Research

Published on 08 May 2026

From body composition to reflux esophagitis: an interpretable machine learning model based on CT-derived features

in Gastrointestinal Sciences

Tianyi Wang
Lu Chen
Yajie Li
Qi Zhang
Xilong Ou
Qin Lu

Frontiers in Physiology

doi 10.3389/fphys.2026.1788389

307 views

Review

Published on 01 May 2026

Pancreatitis: correcting CFTR expression and function as a promising effective treatment

in Gastrointestinal Sciences

Paramita Sarkar
Wei-Yin Lin
Ava Movahed Abtahi
Woo Young Chung
Shmuel Muallem

Frontiers in Physiology

doi 10.3389/fphys.2026.1813824

536 views

Original Research

Published on 01 May 2026

Ductal epithelial MXD3 promotes disease progression in acute pancreatitis through Wnt/β-catenin-mediated inflammation and injury

in Gastrointestinal Sciences

Xianru Jia
Bingbing Cui
Xuejin Liu

Frontiers in Physiology

doi 10.3389/fphys.2026.1785500

437 views

Review

Published on 30 Apr 2026

Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective

in Gastrointestinal Sciences

Fabian M. Cortés-Mancera
Marianne G. Rots
Han Moshage
Johanna C. Arroyave-Ospina

Frontiers in Physiology

doi 10.3389/fphys.2026.1787963

589 views

Review

Published on 28 Apr 2026

Bioactive compounds as therapeutic modulators of metabolic syndrome: targeting inflammation and gut microbiota regulation

in Gastrointestinal Sciences

Magdalene Eno Udobi
Mercy Bella-Omunagbe
Israel Sunmola Afolabi
Shalom Nwodo Chinedu

Frontiers in Physiology

doi 10.3389/fphys.2026.1766078

592 views

Original Research

Accepted on 27 Apr 2026

L-type Ca²⁺ channels dominate in human lower esophageal sphincter sling and clasp fibers

in Gastrointestinal Sciences

Shi-Chang Yu
Jun Feng Liu

Frontiers in Physiology

190 views

Perspective

Published on 15 Apr 2026

Assessment of gut-brain interactions: reframing DGBI symptoms from visceral hypersensitivity to computational interoceptive overfitting

in Gastrointestinal Sciences

Dakai Zeng
He Zeng
Zi Lin
Wen-Jing Yan

Frontiers in Physiology

doi 10.3389/fphys.2026.1817832

478 views

Original Research

Published on 15 Apr 2026

A model for Crohn’s disease post-ileal resection fibrosis development using human ileal enteroids and myofibroblasts

in Gastrointestinal Sciences

Jun Hwan Yoo
Yoon Jeong Choi
Iryna V. Pinchuk
Don W. Powell
Nicholas C. Zachos
Mark Donowitz

Frontiers in Physiology

doi 10.3389/fphys.2026.1764088

627 views

Brief Research Report

Published on 10 Apr 2026

Combined use of EUS, ESD, and laparoscopic techniques in the diagnosis and treatment of a mucinous adenocarcinoma of the ascending colon originating from the submucosal layer: a case report

in Gastrointestinal Sciences

Zongyao Liu
Yanling Li
Rong Tan
Ainizhati Abudusaimaiti
Shengjuan Hu
Ximei Li

Frontiers in Physiology

doi 10.3389/fphys.2026.1745668

362 views

Original Research

Published on 27 Mar 2026

The attenuated incretin effect is associated with glucose intolerance in patients with hepatitis B-related acute-on-chronic liver failure

in Gastrointestinal Sciences

Meichuan Li
Han Hu
Yujuan Liu
Xiaohuan Wu
Yin Zhang
Ying Li
Fangwan Yang
Yan Li
Shide Lin

Frontiers in Physiology

doi 10.3389/fphys.2026.1794931

441 views

Review

Published on 25 Mar 2026

Artificial intelligence-driven gastrointestinal functional assessment: multimodal imaging, digital biomarkers, and real-time monitoring

in Gastrointestinal Sciences

Liucheng Li
Fang Lv
Chen Du
Lianjun Yang
Chengzhou Pa
Yunrui Dai

Frontiers in Physiology

doi 10.3389/fphys.2026.1778235

691 views
1 citation

Original Research

Accepted on 19 Mar 2026

Grad-CAM based Deep Learning Analytics for Image-level Colon Disease Classification based on Graph Neural Networks and Vision Transformers

in Gastrointestinal Sciences

Umar Muhammad Ibrahim
Kavimbi Chipusu
Chaohui Zhen
Biao Zheng
Gugiun Yao
Rui Liang

Frontiers in Physiology

259 views

Original Research

Published on 19 Mar 2026

Impact of arm position and load on upper and lower esophageal sphincter pressures

in Gastrointestinal Sciences

Petr Bitnar
Adam Kurka
Andrew Busch
Tereza Stehnova
Katerina Madle
Jan Stovicek
Alena Kobesova

Frontiers in Physiology

doi 10.3389/fphys.2026.1735342

532 views

Review

Published on 19 Mar 2026

Epigenetic reprogramming in metabolic dysfunction–associated steatotic liver disease: from metabolic memory to precision medicine

in Gastrointestinal Sciences

Basile Njei
Yazan A. Al-Ajlouni

Frontiers in Physiology

doi 10.3389/fphys.2026.1791638

744 views

Review

Published on 13 Mar 2026

Targeted therapeutics for pancreatitis

in Gastrointestinal Sciences

Tareq Alsaleh
John George

Frontiers in Physiology

doi 10.3389/fphys.2026.1795419

885 views
1 citation

Review

Published on 12 Mar 2026

Patient-centered gastrointestinal function assessment technologies: a paradigm shift from traditional approaches to non-invasive innovations

in Gastrointestinal Sciences

Qian Zhu
Qian Li
Yan Zan
Yuchen Lu
Liangjun Xia
Youbing Xia
Tiancheng Xu

Frontiers in Physiology

doi 10.3389/fphys.2026.1776210

633 views

Perspective

Published on 12 Mar 2026

Reconceptualizing negative endoscopy as a positive contextual indicator for disorders of gut-brain interaction

in Gastrointestinal Sciences

Wumiao Zhang
He Zeng
Qian-Nan Ruan
Dakai Zeng

Frontiers in Physiology

doi 10.3389/fphys.2026.1795494

460 views

Original Research

Published on 26 Feb 2026

Prolactin and oxytocin as modulators of intestinal contractility and glucose uptake

in Gastrointestinal Sciences

Perla Alejandra Figueroa-Carrasco
Aída Jimena Velarde-Salcedo
Carmen Gonzalez

Frontiers in Physiology

doi 10.3389/fphys.2026.1703887

1,066 views

Original Research

Published on 23 Feb 2026

Effect of enteral nutrition support combined with prone position mechanical ventilation on respiratory function, nutritional status, and inflammatory response in patients with severe pneumonia

in Gastrointestinal Sciences

Li Xu
Ling Xie
Huijuan Wang

Frontiers in Physiology

doi 10.3389/fphys.2026.1739744

486 views

Original Research

Published on 19 Feb 2026

Endoscopic excision for internal and mixed hemorrhoids: a retrospective case series of short-term outcomes

in Gastrointestinal Sciences

Qi Xu
Bingfeng Qiu
Tangzhou Xu
Dandan Zhuang
Junhan Qu

Frontiers in Physiology

doi 10.3389/fphys.2026.1762846

620 views

Review

Published on 17 Feb 2026

The role of bile acid-activated receptor TGR5 in inflammation and liver diseases

in Gastrointestinal Sciences

Hongyan Xiang
Huanyu Xiang
Shuyun Wang
Peiyu Wu
Zhidan Luo
Jie Zhang

Frontiers in Physiology

doi 10.3389/fphys.2026.1747341

1,186 views
1 citation

Original Research

Published on 06 Feb 2026

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids

in Gastrointestinal Sciences

Svenja Mareike Pauer
Alina Schindler
Parviz Ghezellou
Bernhard Spengler
Martin Diener
Jasmin Ballout

Frontiers in Physiology

doi 10.3389/fphys.2026.1738447

1,078 views

591 articles

articles

Cholestatic and autoimmune liver diseases, bile duct injury, oxidative stress, and therapeutic strategies

Lacticaseibacillus rhamnosus HN001 enhances intestinal barrier function and protects the blood-brain barrier from inflammatory disruption in vitro

From body composition to reflux esophagitis: an interpretable machine learning model based on CT-derived features

Pancreatitis: correcting CFTR expression and function as a promising effective treatment

Ductal epithelial MXD3 promotes disease progression in acute pancreatitis through Wnt/β-catenin-mediated inflammation and injury

Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective

Bioactive compounds as therapeutic modulators of metabolic syndrome: targeting inflammation and gut microbiota regulation

L-type Ca²⁺ channels dominate in human lower esophageal sphincter sling and clasp fibers

Assessment of gut-brain interactions: reframing DGBI symptoms from visceral hypersensitivity to computational interoceptive overfitting

A model for Crohn’s disease post-ileal resection fibrosis development using human ileal enteroids and myofibroblasts

Combined use of EUS, ESD, and laparoscopic techniques in the diagnosis and treatment of a mucinous adenocarcinoma of the ascending colon originating from the submucosal layer: a case report

The attenuated incretin effect is associated with glucose intolerance in patients with hepatitis B-related acute-on-chronic liver failure

Artificial intelligence-driven gastrointestinal functional assessment: multimodal imaging, digital biomarkers, and real-time monitoring

Grad-CAM based Deep Learning Analytics for Image-level Colon Disease Classification based on Graph Neural Networks and Vision Transformers

Impact of arm position and load on upper and lower esophageal sphincter pressures

Epigenetic reprogramming in metabolic dysfunction–associated steatotic liver disease: from metabolic memory to precision medicine

Targeted therapeutics for pancreatitis

Patient-centered gastrointestinal function assessment technologies: a paradigm shift from traditional approaches to non-invasive innovations

Reconceptualizing negative endoscopy as a positive contextual indicator for disorders of gut-brain interaction

Prolactin and oxytocin as modulators of intestinal contractility and glucose uptake

Effect of enteral nutrition support combined with prone position mechanical ventilation on respiratory function, nutritional status, and inflammatory response in patients with severe pneumonia

Endoscopic excision for internal and mixed hemorrhoids: a retrospective case series of short-term outcomes

The role of bile acid-activated receptor TGR5 in inflammation and liver diseases

Proinflammatory cytokines modify Ca2+ signaling and induce an apoptotic lipidome in murine small intestinal organoids