CASE REPORT article
Front. Stroke
Sec. Acute Stroke and Interventional Therapies
Volume 4 - 2025 | doi: 10.3389/fstro.2025.1594351
Bilateral carotid stenosis treated with staged bilateral angioplasty
Provisionally accepted- University of Texas Medical Branch at Galveston, Galveston, United States
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Introduction. Carotid atherosclerotic disease (CAD) is a major cause of stroke, often requiring a combination of medical and surgical interventions. Current guidelines have established well the role of interventions such as carotid endarterectomy and carotid artery stenting (CAS) for unilateral carotid disease. However, there is still a paucity of evidence on the timing, procedural order, and complication rate of these procedures when there is bilateral carotid involvement. Hyperperfusion syndrome (HPS), with or without associated intracerebral hemorrhage, although rare, is a major source of morbidity and mortality after carotid interventions, especially in the setting of bilateral CAD. In select cases, staged bilateral CAS (BCAS) appears to attenuate periprocedural risks, including HPS. Case Report. A 62-year-old male presented with acute dysarthria and right-sided face and upper extremity weakness, amounting to an initial NIHSS of 6. Emergent neuroimaging revealed a dense left MCA sign, complete occlusion of the left proximal internal carotid artery (ICA), and severe stenosis of contralateral ICA. The patient received intravenous thrombolysis and underwent perfusion imaging for possible mechanical thrombectomy. Though imaging was favorable for endovascular recanalization, the patient continued to clinically improve to an NIHSS of 3 during angiography, which showed interval recanalization of left proximal ICA, so the procedure was aborted in favor of a delayed staged BCAS. On the day of the first procedure, angiography revealed interval recanalization of distal ICA and collateral flow to MCA territory associated with early hyperemia. Risks of symptomatic CAS in the light of these findings were discussed with the patient, and a shared decision was made to first pursue endovascular treatment of the asymptomatic severe right CAD, followed by treatment of the symptomatic left CAD, to avoid periprocedural complications such as HPS. The patient continued to improve clinically after both procedures and was able to attain functional independence and resume all previous activities following interventions. Conclusion. This case and literature review suggest that, although both simultaneous and staged BCAS may be feasible treatment options for bilateral CAD, staged BCAS appears to have fewer periprocedural complications such as hyperperfusion syndrome.
Keywords: Carotid artery stenosis, carotid artery occlusion, Angioplasty, Stenting, carotid artery disease, bilateral carotid artery stenosis
Received: 15 Mar 2025; Accepted: 02 Jul 2025.
Copyright: © 2025 Frade, Kaur, Aigbogun, Memon and Shaltoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Heitor Frade, University of Texas Medical Branch at Galveston, Galveston, United States
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