Frontiers in Virology | Systems Virology

Original Research

Published on 22 Aug 2025

Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enable RNA virus discovery

in Systems Virology

Rachid Tahzima
Justine Charon
Adrian Diaz
Kris De Jonghe
Sebastien Massart
Thierry Michon
Wim Vranken

Frontiers in Virology

doi 10.3389/fviro.2025.1501616

609 views

Methods

Published on 23 Apr 2024

NeoRdRp2 with improved seed data, annotations, and scoring

in Systems Virology

Shoichi Sakaguchi
Takashi Nakano
So Nakagawa

Frontiers in Virology

doi 10.3389/fviro.2024.1378695

3,381 views
5 citations

Perspective

Published on 04 Apr 2024

Consensus statement from the first RdRp Summit: advancing RNA virus discovery at scale across communities

in Systems Virology

Justine Charon
Ingrida Olendraite
Marco Forgia
Li Chuin Chong
Luke S. Hillary
Simon Roux
Anne Kupczok
Humberto Debat
Shoichi Sakaguchi
Rachid Tahzima

Frontiers in Virology

doi 10.3389/fviro.2024.1371958

7,002 views
9 citations

Original Research

Published on 14 Mar 2024

Virological characteristics correlating with SARS-CoV-2 spike protein fusogenicity

in Systems Virology

MST Monira Begum
Kimiko Ichihara
Otowa Takahashi
Hesham Nasser
Michael Jonathan
Kenzo Tokunaga
Isao Yoshida
Mami Nagashima
Kenji Sadamasu
Kazuhisa Yoshimura

Frontiers in Virology

doi 10.3389/fviro.2024.1353661

2,991 views
14 citations

Original Research

Published on 22 Dec 2023

Characterization of the evolutionary and virological aspects of mutations in the receptor binding motif of the SARS-CoV-2 spike protein

in Systems Virology

Yuuka Masuda
Hesham Nasser
Jiri Zahradnik
Shuya Mitoma
Ryo Shimizu
Kayoko Nagata
Akifumi Takaori-Kondo
Gideon Schreiber
The Genotype to Phenotype Japan (G2P-Japan) Consortium
Kotaro Shirakawa

Frontiers in Virology

doi 10.3389/fviro.2023.1328229

2,737 views
5 citations

Original Research

Published on 08 Jun 2023

Linear and multivalent PEGylation of the tobacco mosaic virus and the effects on its biological properties

in Systems Virology

Reca Marian Caballero
Ivonne González-Gamboa
Stephen L. Craig
Nicole F. Steinmetz

Frontiers in Virology

doi 10.3389/fviro.2023.1184095

2,806 views
4 citations

Brief Research Report

Published on 19 May 2022

Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial)

in Systems Virology

Mattia Branca
Annalisa Marinosci
Delphine Sculier
Gilles Wandeler
Sabine Yerly
Marcel Stoeckle
Enos Bernasconi
Dominique L. Braun
Kathrin Neumann
Pietro Vernazza

Frontiers in Virology

doi 10.3389/fviro.2022.855437

1,915 views

Specialty Grand Challenge

Published on 14 Dec 2021

The True Nature of Viruses Elucidated by Systems Virology

in Systems Virology

Kei Sato

Frontiers in Virology

doi 10.3389/fviro.2021.808865

2,650 views