About this Research Topic
Globally the number of people with multiple long-term conditions (MLTCs) is on the rise. For people over the age of 60, living with multiple complex disorders is becoming commonplace, with some conditions tending to form consistent clusters, whereas others may manifest in a variety of combinations. Albeit the impact of various combinations can vary greatly, people living with MLTCs tend to have overall poorer health, reduced quality of life, and increased risk of premature death than those without. People living with MLTCs frequently report reduced mobility and social opportunity, chronic pain, reduced ability to work, and poor mental health. With current healthcare strategies and clinical trials of new drugs focused on the treatment of individual diseases, people living with MLTCs are commonly prescribed numerous medications for long periods of time. This polypharmacy commonly results in adverse health outcomes. There is therefore a global need to better understand: how we can use current treatments more astutely in MLTCs, which biological mechanisms drive the development of new co-occurring conditions, and how to identify them much earlier and prevent clusters with clear risk factor associations.
This Research Topic aims to attract high-quality article submissions which offer insight into: underlying causal mechanisms and disease pathways of MLTCs, new ways of diagnosing emerging early-stage comorbidity, new therapeutic strategies, and targets that may offer improved outcomes, understanding of risk factors in the development of MLTC clusters.
We would look to recruit authors who are conducting research on challenges in polypharmacy, pharmacogenomics, multi-morbidity diagnosis and treatment, patient stratification and companion diagnostics (or personalized/precision medicine approaches), prevention, risk factors and clusters, biological mechanisms and interactions between MLTCs. We would encourage the submission of original research articles and reviews.
This Research Topic aims to attract high-quality article submissions which offer insight into: underlying causal mechanisms and disease pathways of MLTCs, new ways of diagnosing emerging early-stage comorbidity, new therapeutic strategies, and targets that may offer improved outcomes, understanding of risk factors in the development of MLTC clusters.
We would look to recruit authors who are conducting research on challenges in polypharmacy, pharmacogenomics, multi-morbidity diagnosis and treatment, patient stratification and companion diagnostics (or personalized/precision medicine approaches), prevention, risk factors and clusters, biological mechanisms and interactions between MLTCs. We would encourage the submission of original research articles and reviews.
Keywords: multi-morbidity, polypharmacy, MLTCs, pharmacogenomics, personalized medicine, precision medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
