About this Research Topic
Ribosomes precisely govern translation occurring on cytoplasmic mRNA. The synergistic and organized cooperation of various translational factors would ensure that mRNA passes through initiation, elongation, and termination smoothly, consequentially generating proteins of sufficient quantity and high quality. Conversely, dysregulation of three consecutive processes leads to aberrant protein synthesis, resulting in profound implications for mammalian development and human diseases. Accumulating evidence has shown how distinct translational factors interplay with cis-regulatory elements in untranslated regions of mRNA to regulate protein synthesis under normal conditions.
In addition to essential factors, RNA-binding proteins, RNA modifications, and noncoding RNAs have been recently implicated in regulating protein production, forming an additional layer of complexity to translational regulation. However, how these new modulators are linked to specific translational processes and associated with development & disease leaves much to uncover.
In this Research Topic, we aim to publish innovative studies from basic research to translational studies focused on RNA translational regulation in developmental and pathogenic processes. The goal is to focus on how translational features are dynamically regulated during these processes and how new factors/elements are involved in the translational regulation of various diseases, such as cancer and neurologic disorders. Additionally, we are interested in manuscripts reporting the development of new technologies and multi-omics approaches that detect transcriptome-wide protein synthesis and capture specific translational features. Finally, research covering the discovery and identification of translation-targeting drugs that may overcome human disease will be considered.
We welcome submissions of Original Research, Methods, Review, Mini-Review, and Brief Research Report articles, including but not limited to the following themes:
• Novel Regulatory factors/elements in RNA translation
• Dynamic regulation of translation during development, stress, and disease
• State-of-the-art techniques to detect and quantify protein translation and their contributions to the knowledge of protein synthesis and pathological relevance
• Targeting translation to develop novel therapeutic approaches to combat human diseases
In addition to essential factors, RNA-binding proteins, RNA modifications, and noncoding RNAs have been recently implicated in regulating protein production, forming an additional layer of complexity to translational regulation. However, how these new modulators are linked to specific translational processes and associated with development & disease leaves much to uncover.
In this Research Topic, we aim to publish innovative studies from basic research to translational studies focused on RNA translational regulation in developmental and pathogenic processes. The goal is to focus on how translational features are dynamically regulated during these processes and how new factors/elements are involved in the translational regulation of various diseases, such as cancer and neurologic disorders. Additionally, we are interested in manuscripts reporting the development of new technologies and multi-omics approaches that detect transcriptome-wide protein synthesis and capture specific translational features. Finally, research covering the discovery and identification of translation-targeting drugs that may overcome human disease will be considered.
We welcome submissions of Original Research, Methods, Review, Mini-Review, and Brief Research Report articles, including but not limited to the following themes:
• Novel Regulatory factors/elements in RNA translation
• Dynamic regulation of translation during development, stress, and disease
• State-of-the-art techniques to detect and quantify protein translation and their contributions to the knowledge of protein synthesis and pathological relevance
• Targeting translation to develop novel therapeutic approaches to combat human diseases
Keywords: Translation, Ribosome, Development, Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
