Regenerative Medicine in Dermatology

Regenerative medicine represents a rapidly evolving frontier in dermatology, offering new therapeutic possibilities to restore, repair, and rejuvenate damaged or aging skin and adnexal structures. With its foundation in tissue engineering, growth factor therapies, cell-based treatments, and biofabrication technologies, regenerative dermatology is revolutionizing both aesthetic and medical practice.

Unlike other organ systems, the skin offers a unique advantage in accessibility, monitoring, and sampling—making it a highly viable target for translational regenerative research. Over the past decade, applications of regenerative medicine in dermatology have expanded to include treatment of alopecia, chronic wounds, acne scarring, photoaging, and pigmentary disorders, as well as the development of personalized 3D bioprinted skin constructs and organoid models for disease modeling and therapeutic testing.

Despite promising advances, challenges remain in the standardization, validation, and clinical translation of these therapies. The lack of regulatory clarity and the heterogeneity in biomanufacturing practices further complicate widespread clinical adoption. This Research Topic aims to provide a comprehensive overview of current and emerging regenerative strategies in dermatology and to catalyze innovation through the dissemination of high-quality evidence, case-based applications, and expert perspectives.

The collection seeks to:
• Showcase state-of-the-art regenerative therapies in dermatology, from early concepts to clinical application
• Present original research, clinical trials, and translational studies evaluating regenerative technologies for dermatologic conditions
• Explore innovative platforms such as skin organoids and 3D bioprinting for disease modeling, diagnostics, and therapeutic screening
• Highlight the intersection of regenerative techniques with aesthetic dermatology, including stem cells, exosomes, PRP, and biostimulatory agents
• Foster discussion around regulatory pathways, ethical considerations, and the future of personalized regenerative dermatology

Manuscript submissions are welcome in, but not limited to, the following areas:
• Stem cell therapies, including adipose-derived, hair follicle–derived, or umbilical MSCs in dermatologic indications
• Platelet-rich plasma (PRP), exosomes, and growth factor–based treatments in both medical and aesthetic dermatology
• Skin organoids and patient-derived models for disease pathogenesis and drug development
• 3D bioprinting of skin tissue and its clinical and preclinical applications
• Regenerative strategies in wound healing, burn management, or post-procedural recovery
• Biostimulatory fillers (e.g., CaHA, PLLA) and their mechanisms of collagen regeneration
• Comparative studies on efficacy, safety, and longevity of regenerative therapies
• Real-world evidence studies evaluating regenerative products in clinical dermatology
• Regulatory and manufacturing challenges in delivering regenerative products for dermatologic use
• Combination therapies integrating regenerative techniques with energy-based devices, injectables, or surgical approaches

Frontiers in Medicine accepts the following article types: Brief Research Report, Case Report, Clinical Trial, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review and Systematic Review.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Keywords: Regenerative Medicine, dermatology, tissue engineering, 3D skin bioprinting, Stem Cell Therapies, Growth Factor Therapies, Skin Organoids, Platelet-Rich Pasma (PRP)

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.