Advancements in Non-Infectious Uveitis: Emerging Therapies and Novel Drug Administration Route

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About this Research Topic

Submission closed

  1. Manuscript Extension Submission Deadline 27 August 2025

Background

Non-infectious uveitis is a heterogeneous group of intraocular inflammatory diseases that pose significant challenges in ophthalmology. Traditionally, corticosteroids have been the cornerstone of treatment; however, many patients exhibit resistance or experience recurrent inflammatory activity, necessitating long-term use of immunomodulatory drugs. Over the past two decades, the advent of biologic drugs, particularly anti-TNF alpha agents, has revolutionized the therapeutic landscape, offering new hope for cases unresponsive to conventional treatments. Despite these advancements, a subset of patients continues to show inadequate response to anti-TNF therapies, prompting the exploration of alternative biologics targeting interleukin-6, interleukin-1, and B-lymphocytes. Recent studies have highlighted the potential of small molecules, such as kinase inhibitors, in managing uveitis, alongside innovations in drug administration routes and the introduction of biosimilar drugs. These developments underscore the need for ongoing research to optimize treatment strategies and address existing gaps in the field.

This research topic aims to provide a comprehensive update on the management of non-infectious uveitis, with a particular focus on the latest advancements in therapeutic options. The primary objectives include evaluating the efficacy and safety of emerging treatments such as small molecules and biosimilars, exploring new routes of drug administration, and identifying potential indications for these novel therapies. By addressing these questions, the research seeks to enhance our understanding of non-infectious uveitis management and improve patient outcomes.

To gather further insights into the evolving landscape of non-infectious uveitis treatment, we welcome articles addressing, but not limited to, the following themes:

-Efficacy and safety of small molecule inhibitors in uveitis management
-Comparative studies of intravenous versus subcutaneous administration of biologics
-Clinical outcomes and cost-effectiveness of biosimilar drugs
-Case reports on novel therapeutic approaches for refractory uveitis
-Mechanistic studies on new biological targets such as interleukin-6, interleukin-1, and B-lymphocytes
-Long-term follow-up studies on patients treated with anti-TNF alpha agents
-Reviews on the current state and future directions of non-infectious uveitis treatment

Keywords: non-infectious uveitis, TNF, inflammatory eye diseases

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