About this Research Topic
Neuroinflammation, mediated by the formation of multiple damage-associated molecular patterns, cytokines, chemokines, and reactive oxygen species, has been found to be involved in the etiopathology of NDs. Accumulating evidence from clinical and preclinical studies has validated the role of neuroinflammation in NDs. Thus, it is critical to develop a deeper understanding of the molecular and cellular pathways that are altered as part of the neuroinflammatory response.
The main aim of the present Research Topic is to highlight new insights into mechanisms that are responsible for neuroinflammation during the development of NDs and those that could be potential therapeutic targets for the treatment of NDs in the future. Potential topics include but are not limited to the following:
- Small molecules, including damage-associated molecular patterns, involved in neuroinflammation (peptides, non-coding RNA, circular RNA, and others)
- Cytokine signaling influencing neuronal and glial cell communication
- Small molecules and cytokine signaling influencing synaptic integrity and function
- Nucleoproteins modulated by cytokines in neurodegenerative processes
- Cytokine signaling in abnormal protein aggregation and deposition of aging brains
In vitro and in vivo studies investigating the above-mentioned mechanisms are welcome. In addition to original research articles, reviews, systematic reviews, meta-analyses or excellent mini-reviews covering recent progress in the field of ND-associated neuroinflammation are invited. Clinical case reports presenting glia-related neuroinflammatory responses using imaging or histopathological tools are specifically encouraged.
Keywords: Neurodegenerative diseases, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, Neuroinflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.