Decoding Immune-Vascular Dynamics for Lung Repair and Therapeutic Innovation

The field of respiratory medicine and biology is increasingly focused on understanding the immune and vascular regulation of lung injury, repair, and regeneration. The human lung, a critical organ for gas exchange, is constantly exposed to environmental toxins, infections, and injuries from chronic diseases. Despite these challenges, the lung exhibits a remarkable capacity for self-defense, repair, and regeneration, primarily through the complex interplay of immune and vascular mechanisms. Current research highlights the dynamic interactions between the immune system and the vascular network within the lung, which are crucial for maintaining pulmonary health. However, significant gaps remain in our understanding of how these systems coordinate to protect and restore lung function after injury or disease. Recent studies have begun to elucidate the dual role of immune responses in either exacerbating or mitigating lung injuries, as well as the supportive role of the vascular system in transporting essential elements for tissue repair. Despite these advances, there is a pressing need for further investigation into these regulatory mechanisms to develop innovative therapeutic approaches for respiratory diseases.

This research topic aims to explore the intricate processes governing lung injury, repair, and regeneration, with a focus on the roles of immune and vascular systems. The primary objectives include understanding how immune responses influence lung injuries, the role of the vascular network in supporting tissue repair, and the potential for therapeutic interventions that harness these mechanisms. By addressing these questions, the research seeks to uncover new insights that could lead to transformative treatments in respiratory medicine.

To gather further insights into the immune and vascular regulation of lung injury, repair, and regeneration, we welcome articles addressing, but not limited to, the following themes:

- The role of immune cells in lung injury and repair
- Vascular contributions to lung regeneration
- Interactions between immune and vascular systems in pulmonary health
- Mechanisms of immune-mediated lung injury
- Therapeutic strategies targeting immune and vascular pathways
- Advances in understanding chronic lung diseases and their impact on repair mechanisms
- Novel biomarkers for lung injury and regeneration.

Keywords: Lung injury, Lung repair, Lung regeneration, Immune response, Vascular network, Pulmonary health, Respiratory system, Immune-vascular interplay, Respiratory diseases, Therapeutic approaches

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.