Unraveling the Immune Microenvironment in Cancer Patients via Transcriptome and Single-Cell Sequencing during Immunotherapy Combinations

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ORIGINAL RESEARCH

Accepted on 11 Aug 2025

Integrated Multi-omics Analysis of Single-cell and Spatial Transcriptomics Reveals Distinct HPV-associated Immune Microenvironment Features and Prognostic Signatures in Cervical Cancer

Qiuyue Su
Xiangdong Tian
Fucheng Li
Xi Yu
Wenchen Gong
Yurong Chen
Wang Jianan
Siqi Yang
Shaojun Zhang
1 more
Shanshan Yang

doi 10.3389/fimmu.2025.1612623

222 views

ORIGINAL RESEARCH

Published on 22 May 2025

Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer

Tianyue Sun
Yan Chen
Ying-Xuan Chen

doi 10.3389/fimmu.2025.1575829

2,415 views

ORIGINAL RESEARCH

Published on 08 May 2025

Single-cell RNA sequencing reveals adrb1 as a sympathetic nerve-regulated immune checkpoint driving T cell exhaustion and impacting immunotherapy in esophageal squamous cell carcinoma

Qun Li
Shuning Xu
Yulin Ren
Cheng Zhang
Ke Li
Ying Liu

doi 10.3389/fimmu.2025.1520766

2,433 views

ORIGINAL RESEARCH

Published on 09 Jan 2025

Integrated single-cell and bulk transcriptome analysis of R-loop score-based signature with regard to immune microenvironment, lipid metabolism and prognosis in HCC

Long Chen
Houzhi Yang
Xianfu Wei
Jianchao Liu
Xiuxin Han
Chao Zhang
Yongheng Liu
Yan Zhang
Yao Xu
2 more
Jinyan Feng

doi 10.3389/fimmu.2024.1487372

3,280 views
1 citation

ORIGINAL RESEARCH

Published on 07 Jan 2025

The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma

Wuguang Chang
Wuyou Gao
Yawei Wu
Bin Luo
Lekai Zhong
Leqi Zhong
Wenqian Lin
Zhesheng Wen
Youfang Chen

doi 10.3389/fmed.2024.1497312

1,500 views
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