Advancements in Ischemic Retinopathies: Unraveling Molecular Mechanisms and Innovative Therapeutic Avenues

Ischemic retinopathies (IRs), commonly described as the "stroke of the retina," are major contributors to vision loss in diseases such as diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusion. Oxidative stress and inflammatory pathways play a pivotal role in their pathogenesis. In the ischemic retina, an excess of free radicals prompts neurodegeneration alongside glial activation and vascular injury. This detrimental cascade underscores the urgent need to delve deeper into both the condition's molecular underpinnings and its clinical manifestations.

This Research Topic aims to enhance the understanding of ischemic retinopathies through the exploration of novel molecular mechanisms and therapeutic opportunities. By dissecting the roles of oxidative stress and inflammation, and by identifying new biomarkers and targets, this collection seeks to set the stage for the next generation of treatments. Enhanced knowledge here could lead to significant advancements in therapeutic strategies, improving outcomes for patients affected by these challenging conditions.

To advance the field of ischemic retinopathy research, this topic calls for the submission of original studies, comprehensive reviews, and innovative methodological papers. Key areas of interest include, but are not limited to:

• Molecular triggers of oxidative stress and inflammation in IR
• Advances in neuroprotection and vascular repair strategies
• Clinical trials of emerging drugs targeting novel therapeutic points
• Longitudinal studies on disease progression and response to therapy

By bringing together the latest research, we hope to catalyze significant breakthroughs in therapeutic options that can halt or even reverse the damage caused by ischemic retinopathies, thus improving visual prognosis for patients globally.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Policy Brief
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: ischemic retinopathies, diabetic retinopathy, retinopathy of prematurity, retinal vascular occlusion, acute glaucoma, photocoagulation, anti-VEGF

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.