The concept of "reserve" was initially introduced by Stern Y in 2012 within the context of Alzheimer's disease, denoting resistance to disease progression. This concept was subsequently applied to Parkinson's disease and other conditions as well. Subsequent research on the highly plastic cerebellum expanded the definition of "reserve" to encompass compensation and repair mechanisms. Concurrently, the advent of antibody therapies that inhibit amyloid protein deposition in Alzheimer's disease has enabled compensation and repair of brain damage while maintaining this reserve capacity. There is a pressing need to comprehend the concept of "reserve" and devise treatments based on the understanding.
The aim of this Research Topic is to explore novel therapeutic strategies that leverage the brain's "reserve" to compensate for and recuperate lost functions. To achieve this, we aim to elucidate the physiological and mathematical characteristics of reserve capacity in the cerebrum, basal ganglia, and cerebellum, and to examine methods such as brain stimulation, neurotransplantation, or genome editing to activate reserve capacity.
This topic will compile original or review articles concerning the clinical features of reserve, the physiological and computational mechanisms underlying it, clinical biomarkers of reserve, and therapeutic methods employing the “reserve” concept in areas such as Alzheimer's disease, Parkinson's disease, cerebellar ataxia, amyotrophic lateral sclerosis, vascular diseases, and multiple sclerosis.
Keywords: cognitive reserve, multiple sclerosis, cerebellar reserve
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
