Targeting Cancer Metabolic Reprogramming for Cancer Therapy

Cancer cells exhibit a distinct metabolism compared to normal cells, characterized by enhanced glycolysis and glutaminolysis pathways to satisfy the increased demands for energy and biosynthetic precursors. Additionally, key metabolic pathways such as mTOR and PI3K are often deregulated, and many tumor suppressor genes are dysfunctional. By undergoing global metabolic reprogramming and numerous metabolic adaptations, cancer cells can sustain higher proliferative rates and resist apoptosis signals. Recognized as one of the main hallmarks of cancer, metabolic rewiring has become a focus of intensive efforts for discovering new therapeutic targets and new anticancer drugs. Expanding our understanding of the complex interactions and mechanisms of metabolic reprogramming in cancer cells is crucial to aid in the discovery of novel targets for cancer therapy.

This Research Topic aims to publish novel findings in the field cancer metabolism aimed at preventing or treating cancer growth, progression, drug resistance, and metastasis. Topics of interest include, but are not limited to, new findings on the mechanisms of metabolic reprogramming, the discovery of new targets, and the discovery and development of novel therapeutics and strategies that target metabolic dysregulation in cancer cells.

We welcome the submission of Original Research, Review, Mini Review, and Perspective articles in this Research Topic.

Keywords: Cancer Metabolism, Metabolic Reprogramming, Glycolysis, Glutaminolysis, Oxidative Phosphorylation, Pentose Phosphate Pathway, Tumor Suppressor Genes, TP53, PTEN, Oncometabolites, Tumor Microenvironment

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.