Frontiers in Drug Discovery

Original Research

Accepted on 25 Jul 2025

Bioinformatics-Driven Identification and Prioritization of PTSD Targets Based on Published Multi-omic Data

in In silico Methods and Artificial Intelligence for Drug Discovery

Mark Zervas
Allyson Gage
Magali Haas

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1613261

118 views

Mini Review

Published on 26 Jun 2025

AI-driven innovation in antibody-drug conjugate design

in In silico Methods and Artificial Intelligence for Drug Discovery

Heather A. Noriega
Xiang Simon Wang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1628789

2,781 views

Editorial

Published on 10 Jun 2025

Editorial: Pharmacokinetics modeling in the Artificial Intelligence Era

in In silico Methods and Artificial Intelligence for Drug Discovery

Simone Brogi
Patric Schyman
Vishal B. Siramshetty

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1636070

1,091 views

Original Research

Published on 06 Jun 2025

Dual upregulation of miRNA-143 and miRNA-506 in non-small cell lung cancer inhibits proliferation, motility, migration, and tumor growth

in Anti-Cancer Drugs

Archana Shrestha
Md Anamul Haque
Prajesh Shrestha
Margarita Lamprou
Seetharama D. Jois
Constantinos M. Mikelis
George Mattheolabakis

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1584801

1,058 views

Editorial

Published on 04 Jun 2025

Editorial: Enhancing drug discovery through structure-based design and computational techniques

in In silico Methods and Artificial Intelligence for Drug Discovery

Rajesh Kumar Pathak
Dev Bukhsh Singh
Binh P. Nguyen

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1632015

949 views

Original Research

Published on 30 May 2025

Safety and tolerability of a bevacizumab biosimilar (Effivia®) in adult Mexican patients with cancer: a multicenter, observational, prospective clinical study

in Anti-Cancer Drugs

Alberto Alfonso Pimentel-Rentería
David Francisco Cantú de León
Eliseo Neftalí De la Cruz
David Suárez
Manuel Rodulfo Segura
José Gustavo Núñez
Livan Delgado-Roche

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1591991

764 views

Original Research

Published on 15 Apr 2025

Identification of natural compounds as potential inhibitors of Interleukin-23: virtual screening, ADMET, drug-likeness, and dynamic simulation

in In silico Methods and Artificial Intelligence for Drug Discovery

Davood Gheidari
Morteza Mehrdad
Mahan Etedali

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1525533

1,379 views
1 citation

Original Research

Published on 21 Feb 2025

Transduction of hematopoietic stem and progenitor cells by an MECP2 lentiviral vector improves Rett syndrome phenotypes

in Neurological Drugs

Joseph S. Anderson
Jill L. Silverman
Alyse L. Lodigiani
Camilla M. Barbaduomo
Julie R. Beegle

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1545391

1,096 views

Editorial

Published on 20 Feb 2025

Editorial: Exploring drug development with single cell omics analytics and stem cell-based disease models

in Technologies and Strategies to Enable Drug Discovery

Linheng Li
Fuchou Tang
Hongkui Deng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1561985

805 views

Perspective

Published on 19 Feb 2025

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

in Technologies and Strategies to Enable Drug Discovery

K. Taylor
R. Ram
L. Ewart
C. Goldring
G. Russomanno
G. P. Aithal
T. Kostrzewski
C. Bauch
J. M. Wilkinson
S. Modi

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1536756

3,589 views

Review

Published on 29 Jan 2025

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

in Anti-Cancer Drugs

Madison Ambrose
Jeremy Lee
Aleem Syed
Zamal Ahmed
Guang Peng

Frontiers in Drug Discovery

doi 10.3389/fddsv.2025.1520734

3,292 views

Original Research

Published on 03 Jan 2025

Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity

in Technologies and Strategies to Enable Drug Discovery

Stefanie Hoffmann
Philip Hewitt
Isabel Koscielski
Dorota Kurek
Wouter Strijker
Kinga Kosim

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1459424

2,528 views
2 citations

Review

Published on 19 Dec 2024

Targeting steroid receptor coactivators in cancer via small molecule agents

in Anti-Cancer Drugs

Yosi Gilad
Ortal Shimon
David M. Lonard
Bert W. O’Malley

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1514412

1,106 views
1 citation

Editorial

Published on 29 Nov 2024

Editorial: Drug discovery and development explained: introductory notes for the general public

in Technologies and Strategies to Enable Drug Discovery

Bruno O. Villoutreix
Jean-Luc Poyet
Katya Tsaioun

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1528467

1,863 views

Review

Published on 19 Nov 2024

Decoding lung complexity: single-cell sequencing in lung diseases, regeneration, and drug discovery

in Technologies and Strategies to Enable Drug Discovery

Peng Wang
Nan Tang

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1495208

1,739 views

Original Research

Published on 29 Oct 2024

Drug–drug interaction extraction based on multimodal feature fusion by Transformer and BiGRU

in In silico Methods and Artificial Intelligence for Drug Discovery

Changqing Yu
Shanwen Zhang
Xuqi Wang
Tailong Shi
Chen Jiang
Sizhe Liang
Guanghao Ma

Frontiers in Drug Discovery

doi 10.3389/fddsv.2024.1460672

1,297 views