Future Directions and Current Trends in Cellular Therapies

In recent decades, hematopoietic cell transplantation, encompassing both autologous and allogeneic methods, has considerably evolved, establishing itself as a fundamental treatment for various hematological conditions. Despite this progress, the introduction of targeted therapies such as CAR-T cell therapy is prompting a reassessment of autologous transplants' role. Concurrently, allogeneic transplantation remains the only curative treatment for many malignant and non-malignant blood disorders. Advances such as enhanced understanding of histocompatibility, expanded donor registries, refined conditioning regimens, and innovative supportive care have broadened its applications and accessibility.

This Research Topic seeks to impart a thorough comprehension of the current and future landscape of stem cell transplantation within hematologic diseases. It aims to explore recent shifts in clinical practices and management of complications, advances in research, patient-centric outcomes, and issues of equity and access in transplantation therapy. Additionally, it intends to delve into emerging areas and indications for transplantation.

We aim to explore advances and ongoing challenges within hematopoietic cell transplantation. We welcome contributions from a variety of article types including original research, review articles, case reports, and opinion pieces. Contributing articles should focus on, but are not limited to, the following themes:

• The efficacy and safety of autologous stem cell transplantation for lymphoma and myeloma versus CAR-T cell therapy, including patient-reported outcomes.
• Recent advancements in allogeneic transplantation techniques and conditioning regimens.
• Innovative supportive care strategies.
• Management strategies for graft-versus-host disease (GVHD) and infectious complications.
• The role of transplantation in treating non-malignant hematological disorders.
• Exploration of disparities in treatment access across different regions and demographic groups.
• Analysis of global trends in transplantation practices and outcomes.
• Projections for future research and application directions in the field.

Keywords: autologous stem cell transplant, allogeneic stem cell transplant, CAR-T cell therapy, GHVHD, infectious complications, patient reported outcomes, donor selection, reduced intensity conditioning

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.