Exploring Pigmentary Disorders: Pathogenesis to Treatment

Pigmentary dermatoses encompass a critical area of dermatological research due to their substantial impact on individuals, both through direct visible effects and deeper, potentially systemic implications. These disorders, including variations like hyperpigmentation, hypopigmentation, and depigmentation, not only alter appearance but may also signal underlying health issues and lead to significant psychological distress. Recent strides in research have begun to decipher their complex mechanisms, aiming to devise therapies that restore skin color more permanently and uniformly. Despite the existence of multiple treatment modalities, the advent of evidence-based therapies promises greater efficacy across diverse patient populations, steering us toward more precise and adaptive solutions.

This Research Topic aims to deepen the understanding of pigmentary dermatoses by exploring the entire spectrum of these conditions. It is essential to distinguish between the various forms of pigmentary changes to tailor approaches effectively. We are particularly interested in innovations in diagnostic techniques—both non-invasive and invasive—and in methods for evaluating therapeutic outcomes. Contributions will ideally highlight advancements in understanding pathogenesis, disease progression, and response to different treatments, while also addressing practical challenges in clinical management. Through a comprehensive, multidisciplinary approach, this research seeks to not only advance clinical practices but also improve patient quality of life.

To gather further insights into the multifaceted nature of pigmentary dermatoses, we welcome articles addressing, but not limited to, the following themes:

• Comparative studies on hyperpigmentation, hypopigmentation, and depigmentation
• Innovations in diagnostic tools such as dermoscopy, mexametry, skin biopsy, and optical coherence tomography
• Evaluation of new therapeutic techniques and their long-term efficacy
• Impact assessments of pigmentary dermatoses on psychological, social, and economic well-being
• Exploration of the connection between pigmentary disorders and autoimmune diseases
We are specifically interested in clinical trials, case series, review articles, systematic reviews, and meta-analyses that can provide new insights and guide future research and clinical practices.

Keywords: pigmentation, melasma, vitiligo, procedures, peels, lasers, surgery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.