Gene by Environment Interactions in Neurological Diseases

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About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 3 April 2026

  2. This Research Topic is currently accepting articles.

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Background

Neurological diseases are complex disorders influenced by a combination of genetic predispositions and environmental factors. Research has shown that the interaction between genes and environmental factors, such as lifestyle, diet, and exposure to toxins, plays a crucial role in the onset and progression of these diseases. Understanding these interactions can provide deeper insights into disease mechanisms, potentially leading to more effective prevention strategies and therapeutic interventions. Despite advancements in genetic research, the dynamic interplay between genes and the environment remains a significant challenge in the study of neurological diseases. Current studies have made strides in identifying specific genetic markers and environmental triggers, yet the intricate mechanisms of their interactions are not fully understood. This gap in knowledge underscores the need for more comprehensive research to unravel the complexities of gene-environment interactions in neurological diseases.

This Research Topic aims to highlight research looking to elucidate the many interactions between genetic factors and environmental influences in the development and progression of neurological diseases. By addressing this complex relationship, the work of these studies aims to uncover the mechanisms behind the outcomes of these interactions and to identify potential targets for intervention.

To gather further insights into the boundaries of gene-environment interactions in neurological diseases, we welcome articles addressing, but not limited to, the following themes:
- Genetic predispositions and environmental triggers in neurological diseases
- Mechanisms of gene-environment interactions in neurodegenerative diseases
- Epigenetic modifications and their role in neurological disorders
- Environmental influences on gene expression and disease progression
- Development and use of models to study gene-environment interactions
- Impact of lifestyle and environmental interventions on neurological health

We are interested in receiving original research articles, reviews, mini-reviews, and perspectives on these themes. Submissions featuring multidisciplinary collaborations and the use of innovative techniques are particularly encouraged.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Data Report
  • Editorial
  • FAIR² Data
  • FAIR² DATA Direct Submission
  • General Commentary
  • Hypothesis and Theory
  • Methods

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Data Report
  • Editorial
  • FAIR² Data
  • FAIR² DATA Direct Submission
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Systematic Review
  • Technology and Code

Keywords: gene-environment interactions, neurological diseases, genetic predisposition, environmental triggers, epigenetics, neurodegenerative diseases, gene expression, disease progression, lifestyle interventions, environmental influences

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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