Organelle Burnout in the Face of a Sugar Storm

In the realm of cellular biology, chronic hyperglycemia stands as a pivotal factor adversely affecting cellular health through mechanisms involving oxidative stress and inflammation.
This Research Topic aims to elucidate the pathways through which chronic metabolic stress precipitates organelle dysfunction, focusing on key processes such as the unfolded protein response (UPR) and mitochondrial decay, which foster inflammation and cell mortality, exacerbating tissue deterioration in metabolic diseases. These internal manifestations need an external stimulus, and that interaction is via the gut microbiome. We intend to dissect the signaling pathways that lead to such cascading failures, understanding their operational mechanics in disease contexts.

To achieve a comprehensive understanding within set boundaries, we expect submissions that delve into the nuanced interactions between hyperglycemia and organelle health, alongside the influence of dietary and environmental factors. We encourage articles on, but not limited to, the following themes:

- Chronic hyperglycemia's impact on organelle functionality;
- UPR's role in metabolic inflammation;
- Mitochondrial dysfunction and oxidative stress interrelations in metabolic disorders;
- The effects of gut microbiome imbalances on metabolic health;
- Advanced diagnosis and Innovative treatment methods for enhancing cellular resilience and organelle preservation in hyperglycemic conditions.

The insights derived from these submissions will guide future research directives and refine therapeutic and diagnostic innovations, fostering a multidisciplinary dialogue essential for advancing our understanding of metabolic disease progression and management. Manuscripts may include experimental research papers, review articles, lab protocols, technical reports, clinical studies, and molecular epidemiology studies.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy Brief
• Review
• Systematic Review
• Technology and Code

Keywords: metabolic physiology, microbiome, hyperglycemia, inflammation, diabetes

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.