Mitochondria are central to energy production in cells, and their dysfunction is increasingly implicated in the aging process and the pathogenesis of age-related neurodegenerative diseases. This Research Topic seeks to elucidate the cellular and molecular mechanisms by which mitochondrial dysfunction contributes to brain aging. By gathering insights into the various pathways affected by mitochondrial health, this topic aims to foster the development of novel therapeutic approaches that could enhance mitochondrial function and thereby mitigate the effects of brain aging and associated neurodegenerative disorders.
Mitochondria play a pivotal role in energy metabolism, cellular signaling, and apoptotic pathways. In the aging brain, mitochondrial dysfunction can lead to decreased energy production, increased oxidative stress, and impaired cellular repair mechanisms, all of which contribute significantly to the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. Understanding these processes is crucial as the global population ages, increasing the prevalence of these debilitating conditions and highlighting the need for effective interventions.
We invite contributions that address the following themes within the scope of mitochondrial dysfunction in brain aging:
• Cellular mechanisms leading to mitochondrial dysfunction in aging neurons.
• The impact of genetic and environmental factors on mitochondrial health in the aging brain.
• Emerging therapeutic strategies aimed at restoring mitochondrial function.
• The role of mitochondrial biogenesis and dynamics in maintaining neuronal health during aging.
• Mitochondrial involvement in neuroinflammatory pathways.
• Clinical implications of mitochondrial research for diagnosing and treating age-related neurodegenerative diseases.
We are seeking original research articles, review articles, and brief reports that provide new insights into these areas. Contributions from across neuroscience, molecular biology, pharmacology, and clinical research are particularly welcome, especially those that offer an interdisciplinary perspective on the topic.
Keywords: Mitochondrial Dysfunction, Neurodegeneration, Cellular Signaling, Alzheimer's Disease, Parkinson's
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
