Impact of Diminished Gonadal Function on Metabolic and Cardiovascular Health

Metabolic health is significantly influenced by gonadal function, with conditions such as menopause, hypogonadism, and andropause representing key points of interest due to their impact on hormonal balance. Diminished gonadal function disrupts the normal levels of gonadal hormones, which are crucial in regulating various physiological processes, including cardiovascular health and metabolic functions in peripheral organs. This disruption poses risks and challenges, affecting overall metabolic regulation and exposing individuals to higher risks of cardiovascular diseases and metabolic syndromes. Recent studies have begun to explore the complex roles these hormones play, but significant gaps remain in understanding the breadth of their impact across different populations and specific conditions.

This Research Topic aims to deepen understanding of how variations in gonadal hormone levels due to diminished gonadal function affect overall physiological regulation and cardiometabolic health. It seeks to explore the complex interplay between these hormones and various aspects of physical health, particularly cardiovascular function and metabolic syndrome. Through rigorous investigation, this Research Topic will endeavor to fill these knowledge gaps by answering critical questions about the specific mechanisms through which gonadal hormones influence health and how these effects can vary based on sex, age, and specific hormonal deficiencies.

To gather further insights on this intricate topic, we welcome articles addressing, but not limited to, the following themes:

• Hormonal regulation of cardiovascular function

• Emerging insights into the impact of gonadal hormones on metabolic syndrome

• Sex differences in cardiometabolic health

• The influence of decreased gonadal hormones on inflammation

• Lifestyle interventions and hormonal restoration strategies

• Impact of gonadal hormone changes on the aging process

Research from human subjects, animal models, and cellular studies is solicited to create a comprehensive understanding of this complex issue. This Research Topic is directed at an audience comprising researchers, clinicians, and healthcare professionals working in the fields of endocrinology, cardiology, metabolism, women’s health, and geriatrics.