Lipids and Wasting Disorders in Disease and Aging

As the global population ages and chronic diseases become more prevalent, accompanying conditions such as wasting disorders are also growing in commonality. Wasting disorders such as cachexia and sarcopenia, are characterized by the loss of adipose and muscle tissue mass and function. These conditions often affect patients suffering from chronic diseases such as cancer, inflammatory diseases (ie heart failure, kidney disease, and chronic obstructive pulmonary disease (COPD), as well as the natural aging process. Lipids play a central role in the development and progression of wasting disorders not only as structural components of cell membranes, but also as crucial players in energy metabolism, signaling pathways, and inflammation.

This Research Topic aims to explore the broad role of lipids in the pathophysiology of wasting disorders. Through the collection of relevant manuscripts, we hope to enhance our understanding of the mechanisms behind these disorders, ultimately paving the way for the development of improved preventative and therapeutic strategies.

Topics of interest include, but are not limited to:

- Metabolism of adipose and muscle tissues in disease and aging

- Role of lipids and lipid metabolites in disease and aging

- Identification of disease pathways underlying loss of adipose tissue and muscle function

- Pharmacological regulation of adipose tissue and muscle function

- Nutritional interventions to manage wasting


We are interested in receiving the following types of articles:

Brief Research Report, Data Report, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Systematic Review, and Technology and Code.

Dr. Aaron Zefrin Fernandis is an employee of the Singapore branch of Merck Sharp & Dohme International GmBH, a pharmaceutical company. Dr. Lindsay McDermott works with Constant Systems, a supplier of laboratory equipment. All other Topic Editors declare no Conflicts of Interest.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Lipids, cachexia, metabolism, aging, fatty acids, muscle, adipose tissue, sarcopenia

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.