Inflammatory diseases, including infection or non-infection mediated acute and chronic inflammatory diseases, (such as ARDS, fibrosis, asthma, and COPD in lung tissue; Myocarditis, Pericarditis and Infective Endocarditis in heart tissue; CIDP, AIE and AD in neuron system; and rheumatoid arthritis, inflammatory bowel disease and psoriasis in other organs) continue to impose a significant global health burden due to their persistent and complex nature. Advances in immunology and molecular biology have illuminated profound aspects of inflammatory pathways, such as NF-κB, NLRP3 inflammasome, and pyroptosis, cumulatively contributing to disease progression. Despite the existence of therapeutic measures, a significant portion of patients experience limited treatment efficacy or develop resistance, underlining the necessity for novel therapeutic solutions. Emerging approaches in biologics targeting cytokines, small-molecule inhibitors, and advanced gene-editing technologies like CRISPR-Cas9, hold promising potential in regulating immune responses. This topic explores molecular mechanisms underlying inflammatory diseases and evaluates cutting-edge therapeutic interventions, aiming to contribute to the development of more precise and effective treatments.
This Research Topic aims to rigorously explore and elucidate the molecular mechanisms driving inflammatory diseases, with a special emphasis on disrupted immune pathways like NF-κB, inflammasome activation, and cytokine signaling, alongside their interaction with metabolic and epigenetic regulators. Adopting an integrated multi-omics approach, consisting of genomics, proteomics, and metabolomics, our goal is to unearth novel biomarkers and therapeutic targets. Additionally, this issue will evaluate emerging treatment strategies, including next-generation biologics (e.g., IL-23/IL-17 inhibitors), small-molecule modulators (e.g., selective JAK inhibitors), and advanced technologies like CRISPR-based gene editing and nanomedicine for targeted drug delivery. The introduction of drug repurposing and microbiome-based therapies offers potential solutions to existing treatment challenges such as drug resistance and systemic side effects.
This Research Topic encompasses a wide range of inflammatory diseases, exploring opportunities and challenges through several key themes:
• Molecular mechanisms: Investigation into dysregulated immune pathways including NF-κB, inflammasome, JAK-STAT, as well as epigenetic regulation, panoptosis, and metabolic reprogramming in inflammation. • Biomarkers: Discover novel biomarkers related to various inflammatory diseases, such as cytokines, metabolites, cell debris; and addressing the specific effects of these biomarkers during the progression of the inflammatory diseases. • Novel therapeutics: Examination of next-generation biologics, small-molecule drugs, and emerging technologies such as CRISPR-based gene editing and nanomedicine. • Translational research: Focus on biomarker discovery, drug repurposing, and the translation of anti-inflammatory therapies from preclinical to clinical stages. • Challenges and future directions: Mechanisms of drug resistance, personalized treatment strategies, and the potential for AI-driven drug discovery.
We encourage Original Research Articles, Reviews, Mini-Reviews, Perspectives, and Clinical Trials providing insights or advancements in mechanistic or therapeutic domains of inflammatory diseases. Contributions integrating interdisciplinary studies, omics data, bioinformatics, and experimental models are particularly welcome.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Opinion
Original Research
Perspective
Policy Brief
Review
Technology and Code
Keywords: molecular mechanism, drug development, inflammatory disease, fibrosis, regeneration
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
