Recent Innovations in Toxicogenomics for Environmental Safety

Toxicogenomics is an interdisciplinary field that integrates toxicology with high-throughput genomic technologies to study how genes respond to toxicant exposure. By combining genomics, transcriptomics, proteomics, and metabolomics, it provides a systems-level understanding of the molecular events underlying toxicity. This approach enables early detection of toxic effects, elucidation of mechanisms of action, and prediction of adverse outcomes before they manifest clinically.

Originally developed for pharmaceutical safety evaluation, toxicogenomics now plays a vital role in environmental health, occupational safety, food safety, and regulatory toxicology. It also contributes to identifying vulnerable populations, understanding gene–environment interactions, and advancing precision toxicology. With the rapid expansion of large-scale data and computational tools, toxicogenomics is increasingly recognized as a transformative tool for next-generation hazard identification and risk assessment.



This Research Topic aims to bring together innovative studies and interdisciplinary approaches that apply toxicogenomics to understand, predict, and mitigate the toxicological effects of chemicals, pharmaceuticals, environmental pollutants, and emerging contaminants. We invite contributions (Original Research Articles, Reviews, Mini Reviews, Case Studies, or Data Reports) on the following themes of interest (but not limited to):

• Technological Innovations in Toxicogenomics

• Environmental Toxicogenomics

• Toxicogenomics of emerging contaminants (Nanomaterials, endocrine disruptors, PFAS, other novel toxicants, etc.)

• Ethical, legal, and social aspects of toxicogenomic research

All submissions will undergo peer review to ensure quality and relevance. Authors are encouraged to present clear implications for toxicogenomic advancement and its role in shaping safer policies and practices

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy Brief
• Review
• Systematic Review
• Technology and Code

Keywords: Toxicogenomics, Biomarkers, Environmental Toxicology, Translational Toxicology, Emerging Contaminants

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.