Recombinant humanized collagen (rhCOL) represents a revolutionary advancement in biomaterials, offering superior biocompatibility, tunable properties, and reduced immunogenicity compared to animal-derived counterparts. In dermatology, rhCOL is pivotal for addressing global skin health challenges, including chronic wounds, aging-related degeneration, and disorders such as psoriasis and eczema. This special issue aims to harness cutting-edge research on rhCOL’s functional mechanisms—focusing on its roles in cellular signaling, tissue regeneration, and barrier enhancement—to accelerate clinical translation. By compiling high-impact studies, this issue will foster interdisciplinary dialogue among researchers, clinicians, and industry stakeholders, addressing the urgent need for evidence-based innovation in dermatological care.
The primary aim of this special issue is to explore the functional underpinnings of recombinant human collagen (rhCOL) in dermatological contexts, with particular emphasis on its molecular interactions, biomechanical properties, and therapeutic efficacy. The scope encompasses original research, reviews, and case studies that investigate rhCOL's diverse applications in skin repair, anti-aging formulations, and disease management. Key topics include the molecular mechanisms by which rhCOL modulates fibroblast activity, collagen synthesis, and inflammation; in vitro and in vivo functional studies on wound healing, scar reduction, and epidermal regeneration; and clinical trials evaluating the effectiveness of rhCOL-based therapies for treating dermatoses, burns, and pursuing cosmetic enhancements. Additional considerations are given to the safety, efficacy, and regulatory aspects of incorporating rhCOL in commercial products. This issue also features research on collagen biomaterials and explores expanded dermatological applications, such as for the mucosal epithelium, while retaining a central focus on the fundamental research objectives related to rhCOL.
This special issue will highlight emerging topics such as the role of rhCOL in personalized medicine (e.g., for dermal skin implants) and its integration with new technologies, including 3D bioprinting and artificial intelligence (AI). Manuscripts may include original research, systematic reviews, mini-reviews, case series, and perspectives. Topics of interest include, but are not limited to: Contributions are expected to provide functional insights in the following areas: o Mechanistic studies elucidating how rhCOL enhances skin elasticity and hydration through protein-protein interactions o Translational research linking laboratory findings to patient treatment outcomes, including efficacy across different populations o Reviews of current challenges (such as scalability and long-term biocompatibility) to guide future innovation. o Expected outcomes include advancing evidence-based guidelines for rhCOL use, reducing treatment costs, and improving the quality of life for patients with skin conditions.
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