Sex Differences in Aging

Recent studies increasingly reveal sex-differences in aging and aging-associated disease. For example, across human populations, women consistently exhibit greater life expectancy than men. Critical aging-associated diseases including neurodegenerative disease, obesity, diabetes and cancer show sex-differences in prevalence and/or complications. Modeling, genetic sequencing, and directed evolution experiments support a role for sexual conflict and sexual antagonistic pleiotropy in the evolution of aging. Both sex chromosome content and sex-biased hormone levels are implicated as causal factors in sex-differences in aging. In addition, age of sexual maturation and reproductive history are implicated in modulating aging. Small molecule, dietary and genetic interventions in aging often show sex-biased effects in model systems and in human subjects. As a consequence, sex is increasingly appreciated as an important factor to consider in designing personalized interventions in aging and aging-associated disease.

Proposed topics include:

Sex hormone effects on aging
Menopause and andropause effects in aging
Sex differences in immune function in aging
Regulation of aging by the gonad
Sex differences in organ aging
Sex differences in neurodegenerative disease
Aging of the reproductive system
Sex differences in mitochondrial function in aging
Effects of mating and reproduction on aging
Evolution of sex differences in aging
Dosage compensation and X inactivation in aging
Y chromosome loss in aging
Sex-specific interventions in aging
Transgender aging
Sex by diet interactions in aging
Sex differences in senescence

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• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
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Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Sex Differences in Aging, Hormonal Regulation, Aging-Associated Diseases, Genetic and Evolutionary Mechanisms, Personalized Interventions

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