Nano-Engineered Scaffolds and Matrices for Regenerative Medicine and Organ-on-a-Chip Systems

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 20 March 2026 | Manuscript Submission Deadline 20 July 2026

  2. This Research Topic is currently accepting articles.

Background

Over the past decade, advances in nanotechnology, biomaterials engineering, and 3D bioprinting have transformed regenerative medicine. These innovations have enabled the development of nano-engineered scaffolds and strategies for delivering cells, growth factors, nucleic acids, and drugs, thereby advancing organ regeneration and the recapitulation of human physiology for disease modelling. However, significant challenges remain in fully replicating organ function or complex physiological environments on a chip. A timely collection of articles on “Nano-Engineered Scaffolds and Matrices for Regenerative Medicine and Organ-on-a-Chip Systems” will highlight how these emerging materials can be harnessed to create advanced models for studying human disease and tissue regeneration.

The Research Topic aims to consolidate the most innovative approaches and advancements in overcoming the above-mentioned limitations. More specifically, nano-engineered scaffolds that can fine-tune/modulate immune cells for tissue regeneration and organ-on-chip models, where innovative approaches are made to introduce vasculature and recapitulate dynamics at the tissue level interface. By spotlighting these innovations, we seek to advance translational research, reduce the number of animals used in research, and ultimately enable breakthroughs in research that can take the leap from the bench to bedside.

We will accept Original Research and Review articles. We welcome papers addressing, but not limited to, the following themes:

• Nano-engineered scaffolds for regenerative medicine
• Nanoparticle embedded scaffolds for tissue engineering
• Nano-fabricated materials used as sensors (biomarker detection, studying cell behavior, etc.)
• Micro-physiological systems for diagnostics and drug screening
• Organ-on-chip models that replicate the organ microsystems

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Editorial
  • FAIR² Data
  • FAIR² DATA Direct Submission
  • Methods
  • Mini Review
  • Original Research
  • Perspective
  • Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Nanomaterials, Hydrogels, Tissue engineering, In-vitro models, 3D bioprinting

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

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