Endoscopic ultrasound (EUS) has rapidly evolved from a diagnostic tool into a therapeutic platform with expanding applications in gastrointestinal (GI) oncology. This Research Topic will showcase advances that leverage EUS for tumor ablation, intratumoral and locoregional drug delivery, and high-fidelity nodal staging—areas that directly influence resectability, systemic therapy decisions, and patient outcomes.
We invite original research, technical innovations, clinical trials, comparative effectiveness studies, and state-of-the-art reviews that clarify safety, efficacy, workflow, and implementation.
Key themes include:
EUS-guided ablation (RFA, MWA, ethanol/chemonecrosis, photodynamic therapy) across pancreatic, biliary, gastric, and subepithelial tumors
EUS-mediated drug delivery (chemotherapy, immunotherapy, oncolytics, radiopharmaceuticals, nanoparticles, hydrogels) and pharmacokinetic/biologic endpoints
Advanced nodal staging using elastography, contrast-enhanced EUS, AI-assisted image analysis, and optimized tissue acquisition (FNB vs FNA, ROSE, molecular profiling)
Procedural standardization, learning curves, and quality metrics
Patient selection, multidisciplinary pathways, and cost-effectiveness
Safety, complication mitigation, and real-world outcomes
By integrating technical advances with clinical decision-making, this collection aims to define best practices and future directions for EUS in GI oncology, from bench-enabled devices and formulations to bedside algorithms that refine staging, personalize therapy, and expand minimally invasive treatment options.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Classification
Clinical Trial
Community Case Study
Data Report
Editorial
FAIR² Data
General Commentary
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
