This Research Topic in Frontiers in Genetics highlights innovative studies that integrate longitudinal exposomics with genetic and multi-omics data to understand how exposures across the lifespan shape health, aging, and disease. Most exposure studies capture a single timepoint, missing the dynamic interactions between environmental factors, genetic variation, and molecular regulation. Life-course exposomics, spanning prenatal, developmental, adult, and aging stages, offers a framework for linking exposure trajectories to biological mechanisms and precision health outcomes.
We invite empirical, methodological, and review articles that combine temporal exposure data with genomics, epigenomics, transcriptomics, proteomics, metabolomics, or microbiome profiling. Priority will be given to studies that move beyond associations to identify predictive mechanisms and actionable biomarkers. Approaches may include high-throughput functional genomics (e.g., spatial or single-cell omics), machine learning, and real-world exposure monitoring through sensors or digital health data.
We particularly encourage translational and regulatory studies connecting exposome–genome insights to disease prevention, precision risk assessment, and health equity. Ethical and societal dimensions, such as data privacy, fairness, and inclusion of diverse populations, are integral to this emerging field.
Scope includes:
• Longitudinal exposomics from prenatal to aging stages
• Multi-omics integration for gene–environment research
• Computational modeling of exposure–genome mechanisms
• Functional validation of exposome–genome interactions
• Translational and policy applications in predictive toxicology and precision health
This Research Topic will establish Frontiers in Genetics as a leading venue for exposomics research, fostering cross-disciplinary collaboration among exposure scientists, geneticists, and computational biologists to advance predictive and equitable frameworks for human health across the lifespan.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Data Report
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
Mini Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
