Nanobiotechnology and Targeted Immunomodulation for Improved Allograft Survival

This Research Topic brings together advances in nanoparticle-based delivery systems designed to modulate alloimmune responses and promote transplant tolerance. We invite studies on targeted nanoparticles (e.g., MECA‑79‑coated systems) delivering costimulatory blockade or other immunomodulators to lymphoid tissues, modulation of Treg and effector T cell responses, and interactions with stromal cells such as fibroblastic reticular cells. Submissions combining nanobiotechnology, immunoengineering, and transplantation models to enhance allograft survival—either alone or in synergy with conventional immunosuppressants—are particularly welcome.