The underlying mechanisms of pain and inflammation are complex and involve a variety of pathways, making painful and inflammatory diseases a challenge to therapeutics, especially those taking a chronic course. Natural products and synthetic strategies have historically played an important role in drug discovery to treat such disorders, salicylates being one of the many examples used in their clinical management. Although an increasing number of non-clinical and clinical studies have evaluated the effectiveness and safety of multi-target natural and synthetic products and their application in inflammatory and painful diseases, many have failed in either early or late trials, for a variety of reasons. The most common include low selectivity, high incidence of adverse effects and/or unfavorable pharmacokinetics properties of drug candidates, limiting their therapeutic use. In this context, the development of delivery systems approaches is useful and can been applied to overcome some of the limitations in drug discovery, generating therapeutic innovations.
The goals of the present Research Topic are:
1. To contribute with cutting edge evidence on the mechanisms of painful and inflammatory conditions
2. To make available up-to-date information on novel natural and synthetic products which have been investigated to treat pain and inflammation
3. To gain knowledge from clinical and non-clinical studies including those employing animal models of disease
4. It is expected that the studies investigate and discuss that molecular targets and molecular mechanisms of disease as wells as prominent natural and synthetic products with anti-inflammatory and/or analgesic properties
In this Research Topic we welcome original articles, mini-reviews, reviews, commentaries, and perspectives. Manuscripts must focus on any aspects of:
- Novel mechanisms of inflammatory and painful disorders such as (but not limited to) those of chronic course;
- The underlying pathways by which novel natural (e.g. plant, marine molecules) and synthetic products act through to present analgesic and/or anti-inflammatory properties;
- An overview of the basic pharmacokinetic and pharmacodynamic aspects and their implications for the novel natural or synthetic molecules;
- To present the advantages of delivery systems, including comparisons of topical versus systemic treatments.
The Guest Editors of this Research Topic encourage all interested researchers to submit an abstract before submitting their manuscript. Abstract submission deadline: 30 November 2021.
The underlying mechanisms of pain and inflammation are complex and involve a variety of pathways, making painful and inflammatory diseases a challenge to therapeutics, especially those taking a chronic course. Natural products and synthetic strategies have historically played an important role in drug discovery to treat such disorders, salicylates being one of the many examples used in their clinical management. Although an increasing number of non-clinical and clinical studies have evaluated the effectiveness and safety of multi-target natural and synthetic products and their application in inflammatory and painful diseases, many have failed in either early or late trials, for a variety of reasons. The most common include low selectivity, high incidence of adverse effects and/or unfavorable pharmacokinetics properties of drug candidates, limiting their therapeutic use. In this context, the development of delivery systems approaches is useful and can been applied to overcome some of the limitations in drug discovery, generating therapeutic innovations.
The goals of the present Research Topic are:
1. To contribute with cutting edge evidence on the mechanisms of painful and inflammatory conditions
2. To make available up-to-date information on novel natural and synthetic products which have been investigated to treat pain and inflammation
3. To gain knowledge from clinical and non-clinical studies including those employing animal models of disease
4. It is expected that the studies investigate and discuss that molecular targets and molecular mechanisms of disease as wells as prominent natural and synthetic products with anti-inflammatory and/or analgesic properties
In this Research Topic we welcome original articles, mini-reviews, reviews, commentaries, and perspectives. Manuscripts must focus on any aspects of:
- Novel mechanisms of inflammatory and painful disorders such as (but not limited to) those of chronic course;
- The underlying pathways by which novel natural (e.g. plant, marine molecules) and synthetic products act through to present analgesic and/or anti-inflammatory properties;
- An overview of the basic pharmacokinetic and pharmacodynamic aspects and their implications for the novel natural or synthetic molecules;
- To present the advantages of delivery systems, including comparisons of topical versus systemic treatments.
The Guest Editors of this Research Topic encourage all interested researchers to submit an abstract before submitting their manuscript. Abstract submission deadline: 30 November 2021.
