For the past several decades, our understanding of the primary mechanism of autophagy, a pathway targeting cytoplasmic materials for lysosomal degradation and recycling, has expanded tremendously. Autophagy has been associated with a series of diseases, particularly neurological disorders. Recently, increasing evidence has manifested that macroautophagy and selective autophagy are linked to tumour suppression and promotion, infectious and inflammatory diseases, cardiovascular disorders, and high-altitude-related diseases. In the progression of these diseases, autophagy or selective autophagy are closely related to the immune escape of tumour cells, differentiation or ageing of stem/progenitor cells, metabolism reprogramming of somatic cells, microbial infections. Although relevant studies have proposed the mechanism of autophagy in these pathological processes, the roles of autophagy are far from well understood.
This Research Topic aims to discover the role and mechanism of autophagy, mitophagy, ERphagy and lipophage in the pathological processes of diseases (e.g., cancer, cardiovascular diseases, ageing, infectious diseases and toxicology). Furthermore, this Research Topic also involves applying autophagy regulation to clinical practice and benefit the patients.
We welcome Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:
• The mechanism of macroautophagy and selective autophagy in the survival of tumour cells, ageing and differentiation of stem/progenitor cell, and metabolism reprogramming of somatic cell;
• The role and mechanism of hypoxia-induced autophagy in high-altitude-associated diseases;
• Autophagy regulation in SARS-CoV-2 infection and replication in COVID-19;
• New method of autophagy/mitophagy/ER-phagy detection and intervention technology;
• Potential applications of autophagy regulation in disease therapy.
For the past several decades, our understanding of the primary mechanism of autophagy, a pathway targeting cytoplasmic materials for lysosomal degradation and recycling, has expanded tremendously. Autophagy has been associated with a series of diseases, particularly neurological disorders. Recently, increasing evidence has manifested that macroautophagy and selective autophagy are linked to tumour suppression and promotion, infectious and inflammatory diseases, cardiovascular disorders, and high-altitude-related diseases. In the progression of these diseases, autophagy or selective autophagy are closely related to the immune escape of tumour cells, differentiation or ageing of stem/progenitor cells, metabolism reprogramming of somatic cells, microbial infections. Although relevant studies have proposed the mechanism of autophagy in these pathological processes, the roles of autophagy are far from well understood.
This Research Topic aims to discover the role and mechanism of autophagy, mitophagy, ERphagy and lipophage in the pathological processes of diseases (e.g., cancer, cardiovascular diseases, ageing, infectious diseases and toxicology). Furthermore, this Research Topic also involves applying autophagy regulation to clinical practice and benefit the patients.
We welcome Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:
• The mechanism of macroautophagy and selective autophagy in the survival of tumour cells, ageing and differentiation of stem/progenitor cell, and metabolism reprogramming of somatic cell;
• The role and mechanism of hypoxia-induced autophagy in high-altitude-associated diseases;
• Autophagy regulation in SARS-CoV-2 infection and replication in COVID-19;
• New method of autophagy/mitophagy/ER-phagy detection and intervention technology;
• Potential applications of autophagy regulation in disease therapy.
