Hydrophobic Core | List of Frontiers open access articles

Original Research

Published on 08 Oct 2025

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

in Cancer Genetics

Hanan E. Alatwi
Amnah A. Alharbi
Rashid Mir
Othman R. Alzahrani
Abdulrahman H. Alessa
Yousef M. Hawsawi
Mohammed Ali Arishi
Aziz Dhaher Albalawi

Frontiers in Oncology

doi 10.3389/fonc.2025.1679528

1,169 views

Original Research

Published on 08 Oct 2025

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

in Cancer Immunity and Immunotherapy

Yadan Li
Xiaolong Tang
Wenhui Zhao
Xiuwen Si
Yanfang Cui
Yanbin Dong
Yongshuo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680667

380 views

Review

Published on 08 Oct 2025

The tibialis anterior tendon revisited: a unified classification framework across development, evolution, and clinical application

in Evolutionary Developmental Biology

Łukasz Olewnik
Ingrid C. Landfald
Magdalena Ciechanowska
Bento João Abreu
Judney Cley Cavalcante

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1678982

683 views

Original Research

Published on 08 Oct 2025

Development of an AI-driven digital assistance system for real-time safety evaluation and quality control in laparoscopic liver surgery

in Cancer Imaging and Image-directed Interventions

Zi-Yang Peng
Zhi-Bo Wang
Yan Yan
Hao-Qian Peng
Yong-Tai Ma
Yu-Tong Li
Yao-Xing Ren
Jun-Xi Xiang
Kun Guo
Gang Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1678525

564 views

Original Research

Published on 08 Oct 2025

The effective sedative dose of remimazolam for BIS <60 during general anesthesia induction between elderly and non-elderly patients-A randomized controlled trial

in Obstetric and Pediatric Pharmacology

Jun-Li Zheng
Jie-Feng Sun
Qing Han
Si-Ren Shi
Jin Zhou
Wei-Long Wang
Xiao-Dong Huang
Zhen-Feng Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692105

885 views

Perspective

Published on 08 Oct 2025

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford

in Environmental Sensors, Sustainability and Reaching Net-Zero

Collins Otieno Odhiambo
Beatrice Van Puije
Edward Krisiunas
Anafi Mataka

Frontiers in Lab on a Chip Technologies

doi 10.3389/frlct.2025.1693514

145 views

Original Research

Published on 08 Oct 2025

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

in Experimental Therapeutics

Suzanne D. Vernon
Candace Rond
Yifei Sun
Shad Roundy
Jennifer Bell
Bella Rond
David L. Kaufman
Alan B. Cash
Brayden Yellman
Lucinda Bateman

Frontiers in Neurology

doi 10.3389/fneur.2025.1691147

977 views

Original Research

Published on 08 Oct 2025

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

in Neurogenomics

Xin Wang
Zelin Wu
Shaoli Wei
Xinran Zhao
Juan Lin
Fang Zhao
Xiaolei Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676565

495 views

Original Research

Published on 08 Oct 2025

A digital twin of glimepiride for personalized and stratified diabetes treatment

in Pharmacogenetics and Pharmacogenomics

Michelle Elias
Matthias König

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686415

708 views

Original Research

Published on 08 Oct 2025

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

in Comparative Immunology

Hicham Sid
Theresa von Heyl
Sabrina Schleibinger
Romina Klinger
Leah Heymelot Nabel
Hanna Vikkula
Rodrigo Guabiraba
Vanaique Guillory
Ryan Scicluna
Mohanned Naif Alhussien

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680791

808 views

Systematic Review

Published on 08 Oct 2025

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis

in Cardiovascular Endocrinology

Meng Li
Jianli Hu
Yip Han Chin
Han Shi Jocelyn Chew
Wenru Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1681965

705 views

Editorial

Published on 08 Oct 2025

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

in Signaling

Lulong Bo
You Shang
Guochang Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714104

235 views

Original Research

Published on 08 Oct 2025

Personalized causal explanations of a robot’s behavior

in Human-Robot Interaction

José Galeas
Suna Bensch
Thomas Hellström
Antonio Bandera

Frontiers in Robotics and AI

doi 10.3389/frobt.2025.1637574

534 views

Mini Review

Published on 08 Oct 2025

Anti-angiogenesis in human lymphomas. New insights

in Hematologic Malignancies

Domenico Ribatti
Roberto Tamma
Giuseppe Ingravallo
Giorgina Specchia

Frontiers in Oncology

doi 10.3389/fonc.2025.1636332

728 views

Original Research

Published on 08 Oct 2025

Segmentation and regional analysis: labor typologies and geographic inequality in Antofagasta and La Araucanía, Chile

in Work, Employment and Organizations

Osvaldo Blanco
Dasten Julián-Véjar
Alejandro Osorio-Rauld

Frontiers in Sociology

doi 10.3389/fsoc.2025.1636282

853 views

Original Research

Published on 08 Oct 2025

LEM-UNet: an edge-guided network for 3D multimodal images segmentation in focal cortical dysplasia

in Brain Imaging Methods

Qiunan Li
Hao Yu
Manli Zhang
Xiaotong Yuan
Lixin Cai
Guixia Kang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1634606

888 views

Articles

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

The tibialis anterior tendon revisited: a unified classification framework across development, evolution, and clinical application

Development of an AI-driven digital assistance system for real-time safety evaluation and quality control in laparoscopic liver surgery

The effective sedative dose of remimazolam for BIS <60 during general anesthesia induction between elderly and non-elderly patients-A randomized controlled trial

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

A digital twin of glimepiride for personalized and stratified diabetes treatment

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

Personalized causal explanations of a robot’s behavior

Anti-angiogenesis in human lymphomas. New insights

Segmentation and regional analysis: labor typologies and geographic inequality in Antofagasta and La Araucanía, Chile

LEM-UNet: an edge-guided network for 3D multimodal images segmentation in focal cortical dysplasia