EDITORIAL article
Front. Cell Dev. Biol.
Sec. Signaling
Volume 13 - 2025 | doi: 10.3389/fcell.2025.1714104
This article is part of the Research TopicTargeting Pulmonary Endothelium in Acute Lung Injury and Acute Respiratory Distress SyndromeView all 14 articles
Targeting Pulmonary Endothelium in Acute Lung Injury and Acute Respiratory Distress Syndrome
Provisionally accepted
- 1Faculty of Anesthesiology, Changhai Hospital, Navy Medical University, Shanghai, China
- 2Huazhong University of Science and Technology Tongji Medical College Union Hospital, Wuhan, China
- 3Department of Anesthesiology, University of Illinois College of Medicine, Chicago, IL, United States; Department of Pharmacology & Regenerative Medicine, University of Illinois College of Medicine, Chicago, United States
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain major causes of mortality in critical care, despite advances in mechanical ventilation and supportive care (1,2). The pulmonary endothelium, a thin, semipermeable barrier lining the pulmonary vasculature, plays a central role in the pathogenesis of ALI/ARDS. Endothelial dysfunction drives vascular leak, inflammation, and coagulation abnormalities-hallmark features of ALI/ARDS that culminate in alveolar edema and hypoxemia (3,4). This Research Topic, "Targeting Pulmonary Endothelium in Acute Lung Injury and Acute Respiratory Distress Syndrome," brings together 13 articles that dissect the molecular mechanisms of endothelial injury, identify novel biomarkers, and explore endothelial-targeted therapeutic strategies, addressing critical gaps in our understanding of these devastating conditions.
Keywords: Acute Lung Injury, pulmonary endothelium, biomarker, heparin-binding protein, Endothelial barrier function
Received: 27 Sep 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Bo, Shang and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lulong Bo, bartbo@smmu.edu.cn
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.