Mechanical Impact | List of Frontiers open access articles

Original Research

Published on 08 Oct 2025

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

in Neurogenomics

Xin Wang
Zelin Wu
Shaoli Wei
Xinran Zhao
Juan Lin
Fang Zhao
Xiaolei Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676565

605 views

Original Research

Published on 08 Oct 2025

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

in Comparative Immunology

Hicham Sid
Theresa von Heyl
Sabrina Schleibinger
Romina Klinger
Leah Heymelot Nabel
Hanna Vikkula
Rodrigo Guabiraba
Vanaique Guillory
Ryan Scicluna
Mohanned Naif Alhussien

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680791

928 views

Review

Published on 08 Oct 2025

Metabolic regulation of interferon-mediated innate antiviral immunity

in Viral Immunology

Tian Zhong
Qi Cao
Zhiyue Ma
Caiyu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680688

806 views

Original Research

Published on 08 Oct 2025

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

in Cancer Immunity and Immunotherapy

Yadan Li
Xiaolong Tang
Wenhui Zhao
Xiuwen Si
Yanfang Cui
Yanbin Dong
Yongshuo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680667

438 views

Review

Published on 08 Oct 2025

Clinical characteristics and risk factor analysis of overlapping syndromes of COPD-OSA with metabolic syndrome in middle-to-high altitude areas

in Pulmonary Medicine

Yisha Qin
Aniu Aju
Yilin Wan
Mengchen Song
Xingxing Hao
Jiwu Li
Xuefeng Shi

Frontiers in Medicine

doi 10.3389/fmed.2025.1680584

306 views

Original Research

Published on 08 Oct 2025

The prevalence and correlates of falls in adults with attention-deficit/hyperactivity disorder: cross-sectional study

in ADHD

Maraheb M. Alkhalidi
Donald H. Lein
Mansour M. Alotaibi

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1673400

1,375 views

Original Research

Published on 08 Oct 2025

Prediction of compressive strength of high-performance concrete based on multiple machine learning models

in Structural Materials

Kouchen Xiao
Hongjian Zhang
Sijia Wei
Chuanxin Zhu
Jingtong He
Shuai Zhu
Xiaohan Yang

Frontiers in Materials

doi 10.3389/fmats.2025.1698248

583 views

Original Research

Published on 08 Oct 2025

A digital twin of glimepiride for personalized and stratified diabetes treatment

in Pharmacogenetics and Pharmacogenomics

Michelle Elias
Matthias König

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686415

746 views

Original Research

Published on 08 Oct 2025

Impact of roxadustat on anemia management in infected patients undergoing long-term dialysis: a retrospective cohort analysis

in Renal Pharmacology

Lulu Wang
Huimin Qiu
Xinqi Tan
Jing Liu
Ting Yang
Chunming Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695376

712 views

Perspective

Published on 08 Oct 2025

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford

in Environmental Sensors, Sustainability and Reaching Net-Zero

Collins Otieno Odhiambo
Beatrice Van Puije
Edward Krisiunas
Anafi Mataka

Frontiers in Lab on a Chip Technologies

doi 10.3389/frlct.2025.1693514

198 views

Original Research

Published on 08 Oct 2025

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway

in Cardiovascular and Smooth Muscle Pharmacology

Maha Abdulrahman Aldubayan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1694060

706 views

Original Research

Published on 08 Oct 2025

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

in Experimental Therapeutics

Suzanne D. Vernon
Candace Rond
Yifei Sun
Shad Roundy
Jennifer Bell
Bella Rond
David L. Kaufman
Alan B. Cash
Brayden Yellman
Lucinda Bateman

Frontiers in Neurology

doi 10.3389/fneur.2025.1691147

1,193 views

Original Research

Published on 08 Oct 2025

The effective sedative dose of remimazolam for BIS <60 during general anesthesia induction between elderly and non-elderly patients-A randomized controlled trial

in Obstetric and Pediatric Pharmacology

Jun-Li Zheng
Jie-Feng Sun
Qing Han
Si-Ren Shi
Jin Zhou
Wei-Long Wang
Xiao-Dong Huang
Zhen-Feng Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692105

921 views

Original Research

Published on 08 Oct 2025

Impact of IS26 mobilization on genetic manipulation of multidrug-resistant Acinetobacter baumannii

in Antimicrobials, Resistance and Chemotherapy

Yuan Hu
Junjie Zheng
Yanan Gong
Lihua He
Fanliang Meng
Jianzhong Zhang

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1689239

729 views

Original Research

Published on 08 Oct 2025

Dissecting adult plant resistance to stem rust through multi-model GWAS in a diverse barley germplasm panel

in Plant Genetics, Epigenetics and Chromosome Biology

Yuliya Genievskaya
Akerke Maulenbay
Shynbolat Rsaliyev
Saule Abugalieva
Aralbek Rsaliyev
Alibek Zatybekov
Yerlan Turuspekov

Frontiers in Plant Science

doi 10.3389/fpls.2025.1681398

1,486 views

Systematic Review

Published on 08 Oct 2025

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis

in Cardiovascular Endocrinology

Meng Li
Jianli Hu
Yip Han Chin
Han Shi Jocelyn Chew
Wenru Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1681965

825 views

Articles

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Metabolic regulation of interferon-mediated innate antiviral immunity

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

Clinical characteristics and risk factor analysis of overlapping syndromes of COPD-OSA with metabolic syndrome in middle-to-high altitude areas

The prevalence and correlates of falls in adults with attention-deficit/hyperactivity disorder: cross-sectional study

Prediction of compressive strength of high-performance concrete based on multiple machine learning models

A digital twin of glimepiride for personalized and stratified diabetes treatment

Impact of roxadustat on anemia management in infected patients undergoing long-term dialysis: a retrospective cohort analysis

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford

Protective effects of avenanthramide-C against cisplatin-induced cardiotoxicity in rats by attenuating oxidative stress, inflammatory cytokines, and modulating p62–Keap1–Nrf2 pathway

Relationships between fatigue, cognitive function, and upright activity in a randomized trial of oxaloacetate for myalgic encephalomyelitis/chronic fatigue syndrome

The effective sedative dose of remimazolam for BIS <60 during general anesthesia induction between elderly and non-elderly patients-A randomized controlled trial

Impact of IS26 mobilization on genetic manipulation of multidrug-resistant Acinetobacter baumannii

Dissecting adult plant resistance to stem rust through multi-model GWAS in a diverse barley germplasm panel

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis