Wicked Problem | List of Frontiers open access articles

Original Research

Published on 20 Aug 2025

Effect of Lactiplantibacillus plantarum LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler

in Microorganisms in Vertebrate Digestive Systems

Mengjiao Li
Zhongyuan Liu
Chen Chen
Ziqi Liu
Liming Liu

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1622009

369 views

Original Research

Published on 20 Aug 2025

Standing under pressure: hemodynamic effects of abdominal compression type and intensity in healthy adults

in Autonomic Neuroscience

Kishen Mitra
Sameer A. Kunte
Sara E. Taube
Shruthee Sankarlinkam
Liban Mohamed
Eghosa Adodo
Cynthia L. Green
Marat Fudim
Eric S. Richardson

Frontiers in Physiology

doi 10.3389/fphys.2025.1621617

291 views

Mini Review

Published on 20 Aug 2025

The malignant dialogue between cancer-associated fibroblasts and osteosarcoma cells: microenvironment-mediated drug resistance and therapeutic targets

in Cancer Immunity and Immunotherapy

Xiufeng Wang
Cong Luo
Danying Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621521

272 views

Brief Research Report

Published on 20 Aug 2025

Therapeutic effects of striatal dopaminergic modulation on idiopathic dystonia and OCD in humans: insights from the striosome hypothesis

in Motor Neuroscience

Shinichi Matsumoto
Hideki Shimazu
Satoshi Goto

Frontiers in Human Neuroscience

doi 10.3389/fnhum.2025.1621054

339 views

Original Research

Published on 20 Aug 2025

Effect of an emergency/planned cesarean section on the perinatal outcomes of pregnant women with placenta accreta spectrum and their neonates: a retrospective study cohort

in Obstetrics and Gynecological Surgery

Duan Duan
Sumei Wei
Dongmei Tang
Shimao Zhang
Jinzhu Fu
Linbo Cheng
Mi Su
Wenyi Lin
Wen Xiong

Frontiers in Surgery

doi 10.3389/fsurg.2025.1603425

139 views

Original Research

Published on 20 Aug 2025

Rapid, sensitive, and visual detection of porcine rotavirus with RPA-CRISPR/Cas13

in Virology

Yong Mi
Mingyang Dai
Xiaokun Xing
Yang Zhang
Zhiwen Xu
Ling Zhu

Frontiers in Microbiology

doi 10.3389/fmicb.2025.1617955

406 views

Review

Published on 20 Aug 2025

Comprehensive review of macrophage models: primary cells and immortalized lines across species

in Comparative Immunology

Tiansong Ding
Yuhan Du
Bin Yang
Wenfan Tian
Jiapei Li
Jinghong Xie

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640935

244 views

Original Research

Published on 20 Aug 2025

Physical health and cognitive ability factors in predicting retirement adjustment based on machine learning approach: results from the China Health and Retirement Longitudinal Study

in Psychology of Aging

Chenhong Cui
Bolin Zhou
Lin Gao
Dahua Wang
Angela C. Rowe
Bruna S. Nascimento
Hao Zhang
Xiancai Cao

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1601723

434 views

Case Report

Published on 20 Aug 2025

Primary vulval sebaceous carcinoma: rare case report and literature review

in Gynecological Oncology

Kaige Pei
Jiawen Zhang
Mingrong Xi

Frontiers in Oncology

doi 10.3389/fonc.2025.1585840

168 views

Original Research

Published on 20 Aug 2025

Cost shifting or cost cutting by hospitals as a response to reimbursement reform? The case of diagnosis-related groups (DRG) scheme in China

in Health Economics

Jiabi Wang
Jinyun Zhu
Kuan Hu
Yijun Chen
Jinghua Zhang
Xiaoyu Wu

Frontiers in Public Health

doi 10.3389/fpubh.2025.1582001

295 views

Original Research

Published on 20 Aug 2025

Exploratory study on the potential benefits of prophylactic levetiracetam after acute spontaneous intracerebral hemorrhage

in Neurocritical and Neurohospitalist Care

Marc A. Babi
Irina Lishen
Barbara Pierre Louis
Katelyn Woodbury
Anthony Kennedy
Fouad Abuzeid
Amre Nouh

Frontiers in Neurology

doi 10.3389/fneur.2025.1580539

336 views

Original Research

Published on 20 Aug 2025

Virtual reality navigation for the early detection of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sayuri Shima
Reiko Ohdake
Yasuaki Mizutani
Harutsugu Tatebe
Riki Koike
Atsushi Kasai
Epifanio Bagarinao
Kazuya Kawabata
Akihiro Ueda
Mizuki Ito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571429

417 views

Original Research

Published on 20 Aug 2025

Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma

in Skin Cancer

Hongyan Hu
Jing Yang
Jin Miao
Chen Li
Cao Wang
Fengming Ran
Jie Zou
Yi Zhang
Liufang Zhao
Wentao Zhao

Frontiers in Oncology

doi 10.3389/fonc.2025.1485006

204 views

Original Research

Published on 20 Aug 2025

Novel deep learning for multi-class classification of Alzheimer’s in disability using MRI datasets

in Computational BioImaging

Sumaiya Binte Shahid
Maleeha Kaikaus
Md. Hasanul Kabir
Mohammad Abu Yousuf
A. K. M. Azad
A. S. Al-Moisheer
Naif Alotaibi
Salem A. Alyami
Touhid Bhuiyan
Mohammad Ali Moni

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1567219

570 views

Original Research

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1550673

324 views

Case Report

Published on 20 Aug 2025

Combined neoadjuvant chemotherapy and immunotherapy in a hepatitis B virus-positive patient with locally advanced rectal adenocarcinoma: a case report and literature review

in Gastrointestinal Cancers: Colorectal Cancer

Qiyun Li
Xue Wu
Zhibin Xu
Taidong Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1560508

271 views

Articles

Effect of Lactiplantibacillus plantarum LPJZ-658 on caecum microbiota and serum metabolomics of Luhua broiler

Standing under pressure: hemodynamic effects of abdominal compression type and intensity in healthy adults

The malignant dialogue between cancer-associated fibroblasts and osteosarcoma cells: microenvironment-mediated drug resistance and therapeutic targets

Therapeutic effects of striatal dopaminergic modulation on idiopathic dystonia and OCD in humans: insights from the striosome hypothesis

Effect of an emergency/planned cesarean section on the perinatal outcomes of pregnant women with placenta accreta spectrum and their neonates: a retrospective study cohort

Rapid, sensitive, and visual detection of porcine rotavirus with RPA-CRISPR/Cas13

Comprehensive review of macrophage models: primary cells and immortalized lines across species

Physical health and cognitive ability factors in predicting retirement adjustment based on machine learning approach: results from the China Health and Retirement Longitudinal Study

Primary vulval sebaceous carcinoma: rare case report and literature review

Cost shifting or cost cutting by hospitals as a response to reimbursement reform? The case of diagnosis-related groups (DRG) scheme in China

Exploratory study on the potential benefits of prophylactic levetiracetam after acute spontaneous intracerebral hemorrhage

Virtual reality navigation for the early detection of Alzheimer’s disease

Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma

Novel deep learning for multi-class classification of Alzheimer’s in disability using MRI datasets

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Combined neoadjuvant chemotherapy and immunotherapy in a hepatitis B virus-positive patient with locally advanced rectal adenocarcinoma: a case report and literature review